NW-G12, A NOVEL NONCHLORINATED CYCLOHEXAPEPTIDE FROM Streptomyces alboflavus 313

文献类型： 外文期刊

第一作者： Fan, Lixia

作者： Fan, Lixia;Ji, Zhiqin;Wu, Wenjun;Guo, Zhengyan;Fan, Lixia

作者机构：

关键词： NVV-G12;desertomycin A;antibacterial activities;Streptomyces alboflavus 313

期刊名称：CHEMISTRY OF NATURAL COMPOUNDS （ 影响因子：0.809； 五年影响因子：0.708 ）

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收录情况： SCI

摘要： In our continuous investigation of metabolites of Streptomyces alboflavus 313, NW-G12 (1), a novel nonchlorinated analogue of NW-G01, was obtained as a trace constituent in the weak polarity part and a known desertomycin A (2) was also isolated from the fermentation broth in the strong polarity part. The structures of compounds 1 and 2 were established by comprehensive analysis of 1D and 2D NMR spectral data. Moreover, compounds 1 and 2 showed strong antibacterial activities against Bacillus cereus. Staphylococcus aureus, and Bacillus subtilis, with MICs of less than 10 μg/mL, but both show no antibacterial activities against two test gram-negative bacteria.

分类号： O6

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