Design, synthesis and bioactivity evaluation of novel benzophenone hydrazone derivatives

文献类型： 外文期刊

第一作者： Li, Wen-Qun

作者： Li, Wen-Qun;Zhang, Zhi-Jun;Nan, Xiang;Liu, Ying-Qian;Zhao, Xiao-Bo;Wu, Dan;Yan, Li-Ting;Hu, Guan-Fang;Yu, Hai-Tao

作者机构：

关键词： benzophenone hydrozone;thiourea;urea;acaricide;insecticide;structure-activity relationship

期刊名称：PEST MANAGEMENT SCIENCE （ 影响因子：4.845； 五年影响因子：4.674 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： BACKGROUND: Benzophenone hydrazone derivatives are among the most important classes of synthetic insecticides. In an effort to discover new molecules with good insecticidal/acaricidal activities, a series of novel benzophenone hydrazone W-acylated thiourea and urea derivatives was synthesized and bioassayed. RESULTS: All of these compounds exhibited excellent bioactivities against T. cinnabarinus and B. brassicae, especially towards T. cinnabarinus with LC_(50) values ranging from 0.305 to 2.036 mmol L~(-1). Moreover, the acaricidal activities against T. cinnabarinus of compounds 8a-i, 12b-f and 12h were 2.5-5.5-fold that of parent molecule 3 based on the LC_(50) value. CONCLUSION: Based on the observed bioactivities, the structure-activity relationship of these analogs was also discussed. Structure-activity relationships provided information that could direct further investigation on structure modification. Our studies indicated that benzophenone hydrazone W-acylated thiourea and urea derivatives could be used as potential lead compounds for developing novel acaricides and insecticides.

分类号： S4

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