Chemical modification of an acidic polysaccharide (TAPA1) from Tremella aurantialba and potential biological activities

文献类型： 外文期刊

第一作者： Du, XiuJu

作者： Du, XiuJu;Lv, ZhiWei;Zhang, JingSong;Yang, Yan;Tang, QingJiu;Ye, LiBin

作者机构：

关键词： Tremella aurantialba polysaccharide;Acetylation;Deacetylation;Immunostimulating activity;Nitric oxide

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

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收录情况： SCI

摘要： TAPA1 was previously isolated from Tremella aurantialba fruiting bodies. In this paper, an acetylated derivative (TAPA1 -ac) and a deactylated derivative (TAPA1 -deac) of TAPA1 were prepared, and their characterization and immunostimulating activities were reported. Acetylation and deacetylation were found to occur actually by FT-IR and NMR spectra, together with calculational results. The degree of substitution (DS) of acetyl groups in TAPAl-ac was 0.23 and the content was 5.82%, which was higher than those of TAPA1 (0.03% and 0.70%, respectively) and TAPAl-deac (all were zero). Compared with TAPA1, TAPAl-ac showed significant immunostimulation effects on mouse spleen lymphocytes (MSLs) proliferation and nitric oxide (NO) production by macrophages RAW264.7, whereas TAPAl-deac showed markedly lower effects. These findings seemed to suggest that immunostimulating activities, including MSLs stimulation activity and NO production potency, might relate to the DS and content of acetyl groups, indicating that acetylation of TAPA1 was an effective way of enhancing immuno-stimulating activities.

分类号： TS2`TS201.2

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