文献类型: 外文期刊
第一作者: Tang, Zhonglin
作者: Tang, Zhonglin;Liang, Ruyi;Zhao, Shuanping;Wang, Ruiqi;Li, Kui;Liang, Ruyi;Huang, Ruihua
作者机构:
关键词: CNN3;Development;miR-1;Pig;Skeletal muscle
期刊名称:INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES ( 影响因子:6.58; 五年影响因子:6.478 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: The calponin 3 (CNN3) gene has important functions involved in skeletal muscle development. MicroRNAs (miRNAs) play critical role in myogenesis by influencing the mRNA stability or protein translation of target gene. Based on paired microRNA and mRNA profiling in the prenatal skeletal muscle of pigs, our previous study suggested that CNN3 was differentially expressed and a potential target for miR-1. To further understand the biological function and regulation mechanism of CNN3, we performed co-expression analysis of CNN3 and miR-1 in developmental skeletal muscle tissues (16 stages) from Tongcheng (a Chinese domestic breed, obese-type) and Landrace (a Western, lean-type) pigs, respectively. Subsequently, dual luciferase and western blot assays were carried out. During skeletal muscle development, we observe a significantly negative expression correlation between the miR-1 and CNN3 at mRNA level. Our dual luciferase and western blot results suggested that the CNN3 gene was regulated by miR-1. We identified four single nucleotide polymorphisms (SNPs) contained within the CNN3 gene. Association analysis indicated that these CNN3 SNPs are significantly associated with birth weight (BW) and the 21 -day weaning weight of the piglets examined. These facts indicate that CNN3 is a candidate gene associated with growth traits and regulated by miR-1 during skeletal muscle development in pigs.
分类号: Q
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