FLUORIDE-INDUCED CELL CYCLE ARREST, APOPTOSIS, AND DNA DAMAGE IN TM3 MOUSE LEYDIG CELLS

文献类型： 外文期刊

第一作者： Song, Chao

作者： Song, Chao;Yang, Zijun;Guo, Shuzhou;Shang, Zesong;Cao, Xiaodan

作者机构：

关键词： Cell cycle aberration;DNA damage;Fluoride and Leydig cells;Leydig cell apoptosis;Single cell gel electrophoresis;TM3 mouse Leydig cells

期刊名称：FLUORIDE （ 影响因子：1.224； 五年影响因子：1.368 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： This study was designed to evaluate the effect of fluoride (F) on the cell cycle, apoptosis, and DNA damage in TM3 mouse Leydig cells in vitro by the methods of flow cytometry (FCM) and single cell gel electrophoresis (SCGE). TM3 mouse Leydig cells were exposed to 0, 200, 400, 600, and 800 μmol NaF/L for 24 hr. By FCM, the number of cells in G0/G1 phase were much higher, whereas the cells in S phase, G2+M phase, and the proliferation index (PI) value were much lower than in the control group. Moreover, the percentage of Leydig cell apoptosis increased with increasing concentration of F compared with the control group. From SCGE, tail length increased with increasing concentration of F, and the effects were dosedependent. The results show that F can cause cell cycle aberration, induce apoptosis, and DNA damage in cultures of TM3 mouse Leydig cells.

分类号： O61

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