The two-component system NisK/NisR contributes to the virulence of Streptococcus suis serotype 2

文献类型： 外文期刊

第一作者： Xu, Juan

作者： Xu, Juan;Fu, Shulin;Xu, Qiaoxia;Bei, Weicheng;Chen, Huanchun;Tan, Chen;Xu, Juan;Fu, Shulin;Xu, Qiaoxia;Bei, Weicheng;Chen, Huanchun;Tan, Chen;Liu, Manli

作者机构：

关键词： Streptococcus suis serotype 2;NisKR;Virulence

期刊名称：MICROBIOLOGICAL RESEARCH （ 影响因子：5.415； 五年影响因子：6.038 ）

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收录情况： SCI

摘要： Two-component signal-transduction systems (TCSTSs) may regulate some virulence factors in response to external stimuli, and thus allowing Streptococcus. suis serotype 2 to interact with the host, promote survival, and cause disease. Here, a mutant of the NisKR TCSTS had attenuated virulence in vitro, as exemplified by lowered hemolytic activity, reduced adherence to epithelial cells, increased elimination by macrophages, and decreased resistance to killing by neutrophils. Results also showed that this system is important for the ability of S. suis serotype 2 to survive and proliferate in an in vivo mouse model. Thus, the NisKR system plays a significant role in pathogenesis, both in colonization and invasive disease

分类号： Q

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