Effects on liver hydrogen peroxide metabolism induced by dietary selenium deficiency or excess in chickens
文献类型: 外文期刊
第一作者: Xu, Jing-Xiu
作者: Xu, Jing-Xiu;Cao, Chang-Yu;Wang, Li-Li;Li, Nan;Xu, Shi-Wen;Li, Jin-Long;Sun, Yan-Chun
作者机构:
关键词: Catalase;Chicken liver;Hydrogen peroxide;Selenium deficiency or excess;Superoxide dismutase
期刊名称:BIOLOGICAL TRACE ELEMENT RESEARCH ( 影响因子:3.738; 五年影响因子:3.44 )
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收录情况: SCI
摘要: To determine the relationship between dietary selenium (Se) deficiency or excess and liver hydrogen peroxide (H2O2) metabolism in chickens, 1-day-old chickens received insufficient Se (0.028 mg Se per kg of diet) or excess Se (3.0 or 5.0 mg Se per kg of diet) in their diets for 8 weeks. Body and liver weight changes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, H2O2 content, and activities and mRNA levels of enzymes associated with H2O2 metabolism (catalase (CAT) and superoxide dismutase (SOD) 1-3) were determined in the liver. This study showed that Se deficiency or excess Se intake elicited relative severe changes. Se deficiency decreased growth, while Se excess promoted growth in chickens. Both diets vastly altered the liver function, but no obvious histopathological changes were observed in the liver. Se deficiency significantly lowered SOD and CAT activities, and the H2O2 content in the liver and serum increased. Se excess (3.0 mg/kg) decreased SOD and CAT activities with changes in their mRNA levels, and the H 2O2 content increased. The larger Se excess (5.0 mg/kg) showed more serious effects but was not fatal. These results indicated that the H2O2 metabolism played a destructive role in the changes in bird liver function induced by Se deficiency or excess.
分类号: Q5
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