Effects of carbon tetrachloride on oxidative stress, inflammatory response and hepatocyte apoptosis in common carp (Cyprinus carpio)

文献类型： 外文期刊

第一作者： Jia, Rui

作者： Jia, Rui;Wang, Jia-Hao;Liu, Ying-Juan;Xu, Pao;Yin, Guo-Jun;Jia, Rui;Cao, Li-Ping;Du, Jin-Liang;Xu, Pao;Yin, Guo-Jun;Cao, Li-Ping;Du, Jin-Liang;Yin, Guo-Jun;Jeney, Galina

作者机构：

关键词： Carbon tetrachloride;Inflammatory cytokines;Nuclear translocation factor;Apoptosis;Cyprinus carpio

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.964； 五年影响因子：5.071 ）

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收录情况： SCI

摘要： In the present study, the cellular and molecular mechanism of carbon tetrachloride (CCl4)-induced hepatotoxicity in fish was investigated by studying the effects of CCl4 on the oxidative stress, inflammatory response and hepatocyte apoptosis. Common carp were given an intraperitoneal injection of 30% CCl4 in arachis oil (0.5 ml/kg body weight). At 72 h post-injection, blood were collected to measure glutamate pyruvate transaminase (GPT), glutamate oxalate transaminase (GOT), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione (GSH), total antioxidant capacity (T-AOC) and malondialdehyde (MDA), liver samples were taken to analyze toll-like receptor 4 (TLR4), cytochrome P450 2E1 (CYP2E1) and gene expressions of inflammatory cytokines and nuclear factor-kappa B (NF-kappa B/cREL). Cell viability and apoptosis were analyzed after treatment of the primary hepatocytes with CCl4 at 8 mM. The results showed that CCl4 significantly increased the levels of GPT, GOT, MDA, TLR4 and CYP2E1, reduced the levels of SOD, GPx, CAT, GSH and T-AOC, and up-regulated the gene expressions of NF-kappa B/cREL and inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), IL-1 beta, IL-6 and IL-12. In vitro, CCl4 caused a dramatic loss in cell viability and induced hepatocyte apoptosis. Overall results suggest that oxidative stress lipid peroxidation, and TNF-alpha/NF-kappa B and TRL4/NF-kappa B signaling pathways play important roles in CCl4-induced hepatotoxicity in fish

分类号： Q17

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