Multisubstituted indole-acrylonitrile hybrids as potential cytotoxic agents

文献类型： 外文期刊

第一作者： Ke, Shaoyong

作者： Ke, Shaoyong;Yang, Ziwen;Zhang, Zhigang;Liang, Ying;Wang, Kaimei;Liu, Manli;Shi, Liqiao

作者机构：

关键词： Cytotoxic activity;Hybrids;Multisubstituted indole-acrylonitrile;Synthesis

期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.823； 五年影响因子：2.677 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A series of multisubstituted indole-acrylonitrile hybrids were designed, synthesized and evaluated for their potential cytotoxic activities. The bio-evaluation results indicated that some of the target compounds (such as 3a, 3f, 3k, 3n) exhibited good to moderate cytotoxic effect on HepG2, BCG-823, BEL-7402, and HL-7702 cell lines. Especially, the compounds 3a and 3k also exhibited high cytotoxic activities (3a, 19.38 ± 3.38 μM; 3k, 15.43 ± 3.54 μM) against the BEL-7402 cell line resistant to Taxol (>25 μM) and 5-FU (>500 μM), which might be developed as novel lead scaffold for potential anticancer agents.

分类号： R9

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