Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride

文献类型： 外文期刊

第一作者： Li, Zhi-Hua

作者： Li, Zhi-Hua;Chen, Lu;Wu, Yan-Hua;Li, Ping;Li, Yun-Feng;Ni, Zhao-Hui;Li, Zhi-Hua;Li, Ping;Wu, Yan-Hua

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关键词： javax.sql.rowset.serial.SerialClob@10a7161

期刊名称：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY （ 影响因子：4.86； 五年影响因子：4.462 ）

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收录情况： SCI

摘要： Mercury is a prominent environmental contaminant that causes endocrine disorder to human and other organisms. But little is known about the response of the thyroid functions and hypothalamic-pituitary-thyroid (HPT) axis to mercury in teleosts and the few studies that are available have not yielded consistent results. In this study, expression profiles of corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh?, solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr? and thyroid hormone receptor beta (tr? genes were determined in whole-body of Chinese rare minnow (Gobiocypris rarus) larvae after exposure to different levels of Hg2+ (0, 0.1 and 0.3mg/l) for 4 days, as well as the thyroid hormones (THs) levels. Moreover, the 96-h lethal concentration of Hg2+ on rare minnow larvae was determined as 0.32mg/l. The results showed that crh, tg, tr?and tr?mRNA levels were significantly up-regulated in the larvae, but the gene expression of tsh?and slc5a5 was not significantly changed in our study. Besides, the THs levels increased in the whole-body of fish, especially the thyroxine (T4) level. The above results indicated that Hg2+ could alter some genes expression in the HPT axis which could be used as the potential biomarkers for evaluating the environmental Hg2+-induced stress in fish.

分类号： R9

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