Enantioseparation of mandelic acid and alpha-cyclohexylmandelic acid using an alcohol/salt-based aqueous two-phase system

文献类型： 外文期刊

第一作者： Li, Fen-Fang

作者： Li, Fen-Fang;Tan, Zhi-Jian;Guo, Zhi-Feng;Tan, Zhi-Jian

作者机构：

关键词： alcohol/salt aqueous two-phase system;chiral separation;enantiomers;sulfonated beta-cyclodextrin

期刊名称：CHEMICAL PAPERS （ 影响因子：2.097； 五年影响因子：1.831 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： An alcohol/salt-based aqueous two-phase system (ATPS) was employed for enantioseparation of (R,S)-mandelic acid (MA) and (R,S)-alpha-cyclohexylmandelic acid (alpha-CHMA). Sulfonated beta-cyclodextrin (Sf-beta-CD) with different degrees of substitution (DS) was considered as the chiral selector. The ethanol/(NH4)(2)SO4 system showed the optimal chiral recognition ability for MA. To optimize the experimental conditions, Sf-beta-CD concentration, ethanol and salt concentration, temperature, and pH were studied. The recognition ability of enantiomers was mainly dependent on the type of the chiral selector but the ethanol and (NH4)(2)SO4 concentrations also had significant influence on the enantiomeric recognition. The maximum values of alpha and ee (up) of 1.69 and 16.3 % were obtained, respectively, for MA under the optimal conditions. A potential application of this alcohol/salt ATPS is the scale-up of chiral separation of MA.

分类号： O6

  • 相关文献

[1]Response surface methodology for the enantioseparation of dinotefuran and its chiral metabolite in bee products and environmental samples by supercritical fluid chromatography/tandem mass spectrometry. Dong, Fengshou,Li, Shasha,Xu, Jun,Liu, Xingang,Zheng, Yongquan,Zheng, Zuntao,Xu, Yongwei.

[2]Stereoselective Determination of a Novel Chiral Insecticide, Sulfoxaflor, in Brown Rice, Cucumber and Apple by Normal-Phase High-Performance Liquid Chromatography. Dong, Fengshou,Xu, Jun,Liu, Xingang,Cheng, Youpu,Liu, Na,Tao, Yan,Zheng, Yongquan.

[3]Stereoselective Determination of Tebuconazole in Water and Zebrafish by Supercritical Fluid Chromatography Tandem Mass Spectrometry. Liu, Na,Dong, Fengshou,Xu, Jun,Liu, Xingang,Chen, Zenglong,Tao, Yan,Pan, Xinglu,Chen, XiXi,Zheng, Yongquan.

[4]Chiral separation of mandelic acid enantiomers using an aqueous two-phase system based on a thermo-sensitive polymer and dextran. Tan, Zhijian,Li, Fenfang,Zhao, Congcong,Teng, Yubin,Liu, Yanfei,Tan, Zhijian,Tan, Zhijian.

[5]Racemic, R-, and S-tebuconazole altered chitinase and chitobiase activity of Daphnia magna. Qi, Suzhen,Liu, Xue,Zhu, Lizhen,Chen, Xiaofeng,Wang, Chengju,Qi, Suzhen. 2018

[6]Simultaneous enantioselective determination of triazole fungicides in soil and water by chiral liquid chromatography/tandem mass spectrometry. Dong, Fengshou,Liu, Xingang,Xu, Jun,Li, Jing,Kong, Zhiqiang,Chen, Xiu,Liang, Xuyang,Zheng, Yongquan.

[7]Simultaneous enantioselective determination of fenbuconazole and its main metabolites in soil and water by chiral liquid chromatography/tandem mass spectrometry. Dong, Fengshou,Liu, Xingang,Xu, Jun,Li, Jing,Kong, Zhiqiang,Chen, Xiu,Zheng, Yongquan,Song, Wencheng,Wang, Yunhao.

[8]Chiral separation of alpha-cyclohexylmandelic acid enantiomers using ionic liquid/salt aqueous two-phase system. Chen, Lei-Lei,Li, Fen-Fang,Tan, Zhi-Jian.

[9]Green synthesis of a typical chiral stationary phase of cellulose-tris(3,5-dimethylphenylcarbamate). Bai, Lian-yang,Liu, Run-Qiang,Zhang, Yi-Jun,Zhang, Yu-Ping,Bai, Lian-yang. 2013

[10]Enantioselective determination of carboxyl acid amide fungicide mandipropamid in vegetables and fruits by chiral LC coupled with MS/MS. Zhang, Hu,Wang, Xiangyun,Wang, Xinquan,Qian, Mingrong,Xu, Mingfei,Xu, Hao,Qi, Peipei,Wang, Qiang,Zhang, Hu,Wang, Xiangyun,Wang, Xinquan,Qian, Mingrong,Xu, Mingfei,Xu, Hao,Qi, Peipei,Wang, Qiang,Zhuang, Shulin.

[11]Enantioselective determination of triazole fungicide tebuconazole in vegetables, fruits, soil and water by chiral liquid chromatography/tandem mass spectrometry. Dong, Fengshou,Liu, Xingang,Xu, Jun,Li, Jing,Kong, Zhiqiang,Chen, Xiu,Zheng, Yongquan.

[12]HPLC-MS/MS enantioseparation of triazole fungicides using polysaccharide-based stationary phases. Zhang, Hu,Wang, Minghua,Zhang, Hu,Wang, Minghua,Zhang, Hu,Qian, Mingrong,Wang, Xinquan,Wang, Xiangyun,Xu, Hao,Wang, Qiang,Zhang, Hu,Qian, Mingrong,Wang, Xinquan,Wang, Xiangyun,Xu, Hao,Wang, Qiang,Zhang, Hu,Qian, Mingrong,Wang, Xinquan,Wang, Xiangyun,Xu, Hao,Wang, Qiang.

作者其他论文 更多>>

微信小程序