Expression of variant transcripts of the potassium channel tetramerization domain-containing 15 (KCTD15) gene and their association with fatness traits in chickens

文献类型： 外文期刊

第一作者： Liang, S. S.

作者： Liang, S. S.;Ouyang, H. J.;Liu, J.;Chen, B.;Nie, Q. H.;Zhang, X. Q.;Liang, S. S.;Ouyang, H. J.;Liu, J.;Chen, B.;Nie, Q. H.;Zhang, X. Q.;Liang, S. S.;Ouyang, H. J.;Liu, J.;Chen, B.;Nie, Q. H.;Zhang, X. Q.

作者机构：

关键词： KCTD15;Chicken;Gene expression;Fatness;Association analysis

期刊名称：DOMESTIC ANIMAL ENDOCRINOLOGY （ 影响因子：2.29； 五年影响因子：2.297 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The aim of this study was to characterize the structure, expression, and biological functions of potassium channel tetramerization domain containing 15 (KCTD15) in chickens. We compared the KCTD15 expression level in samples of hypothalamic, adipose, and liver tissue of Xinghua chickens that were maintained on different dietary status. An association analysis of KCTD15 gene variant transcripts with fatness traits in a F2 resource population of chickens was performed. Three KCTD15 transcripts were identified in which the complete transcript was predominantly expressed in adipose tissue and the hypothalamus. The chicken Kill) 15 gene was regulated by both feeding and fasting and consumption of a high-fat diet. The expression level of KCTD15 gene was markedly decreased in hypothalamus and liver of fasted and refed chickens (P < 0.05) and significantly downregulated in adipose tissue by the high-fat diet (P < 0.05). Three single-nucleotide polymorphisms of the KCTD15 gene were significantly associated with a number of fatness traits in chicken (P < 0.05). These results suggest that KCTD15 have a potential role regulation of obesity and fat metabolism in chickens. (C) 2015 Elsevier Inc. All rights reserved.

分类号： S856

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