Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity

文献类型: 外文期刊

第一作者: Tang, Yan-Dong

作者: Tang, Yan-Dong;Na, Lei;Fu, Li-Hua;Yang, Fei;Zhu, Chun-Hui;Tang, Li;Wang, Jia-Yi;Li, Zhan;Wang, Xue-Feng;Wang, Xiaojun;Zhou, Jian-Hua;Tang, Yan-Dong;Li, Cheng-Yao;Li, Qiang;Zhou, Jian-Hua

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关键词: EIAV;ADAR1;Infectivity;Replication

期刊名称:VIROLOGY ( 影响因子:3.616; 五年影响因子:3.967 )

ISSN:

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收录情况: SCI

摘要: Adenosine deaminases that act on RNA (ADARs) have been reported to be functional on various viruses. ADAR1 may exhibit antiviral or proviral activity depending on the type of virus. Human immunodeficiency virus (HIV)-1 is the most well-studied lentivirus with respect to its interaction with ADARI, and variable results have been reported. In this study, we demonstrated that equine ADARI (eADAR1) was a positive regulator of equine infectious anemia virus (EIAV), another lentivirus of the Retroviridae family. First, eADAR1 significantly promoted EIAV replication, and the enhancement of viral protein expression was associated with the long terminal repeat (LTR) and Rev response element (RRE) regions. Second, the RNA binding domain 1 of eADAR1 was essential only for enhancing LTR-mediated gene expression. Third, in contrast with APOBEC proteins, which have been shown to reduce lentiviral infectivity, eADAR1 increased the EIAV infectivity. This study indicated that eADAR1 was proviral rather than antiviral for EIAV. (C) 2014 Elsevier Inc. All rights reserved.

分类号: R37

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