luxS/AI-2 Quorum Sensing Is Involved in Antimicrobial Susceptibility in Streptococcus agalactiae
文献类型: 外文期刊
第一作者: Ma, Yan Ping
作者: Ma, Yan Ping;Ke, Hao;Hao, Le;Liu, Zhen Xing;Liang, Zhi Ling;Ma, Jiang Yao;Ma, Yan Ping;Ke, Hao;Hao, Le;Liu, Zhen Xing;Liang, Zhi Ling;Ma, Jiang Yao;Yang, Hu Cheng;Li, Yu Gu
作者机构:
关键词: Streptococcus agalactiae;luxS mutant;AI-2;antimicrobial susceptibility;molecular mechanism
期刊名称:FISH PATHOLOGY ( 影响因子:0.6; 五年影响因子:0.802 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: luxS-mediated autoinducer-2 (AI-2) directly or indirectly regulates important physiologic function in a variety of bacteria, including bioluminescent effect, antimicrobial resistance, virulence factor control, biofilm structure stability and so on. In this study, the regulation of susceptibility to antimicrobials by luxS/AI-2 was investigated in Streptococcus agalactiae. A luxS- knockout mutant strain named SX1 was constructed by homologous recombination from S. agalactiae CNEP110823 (wild type strain), and a luxS-complementation strain named SX2 was constructed from SX1 through transducing a plasmid with the luxS gene and its promoter. Then the susceptibility to cefradine and norfloxacin of these two strains, SX1 exposed to AI-2 precursor molecule 4,5-dihydroxy-2,3-pentanedione (DPD) and the wild type strain was determined by viable bacterial counting. SX1 decreased susceptibility to cefradine and norfloxacin, SX2 returned the susceptibility to the same level as the wild type strain and DPD restored the susceptibility of SX1. The results indicate that luxS/AI-2 quorum sensing is involved in antimicrobial susceptibility in S. agalactiae, which may provide novel clues for antimicrobial therapy in the infection.
分类号: S94
- 相关文献
作者其他论文 更多>>
-
Dietary supplementation of mulberry leaf oligosaccharides improves the growth, glucose and lipid metabolism, immunity, and virus resistance in largemouth bass (Micropterus salmoides)
作者:Zhou, Donglai;Zhong, Wenhao;Fu, Bing;Li, Erna;Li, Qingrong;Yang, Qiong;Zou, Yuxiao;Liao, Sentai;Xing, Dongxu;Zhou, Donglai;Li, Erna;Wang, Fubao;Zhong, Wenhao;Hao, Le;Liu, Zhenxing
关键词:largemouth bass; growth; serum biochemistry; liver metabolism; inflammation
-
Lycorine provides antiviral activities against mandarin fish ranavirus via suppressing apoptosis and activating type I interferon pathway
作者:Jia, Mengyan;Guo, Hui;Jia, Mengyan;Ma, Yanping;Hao, Le;Tao, Ziqian;Wang, Jingya;Liu, Zhenxing;Tao, Ziqian;Wang, Jingya;Liao, Sentai
关键词:MRV; Lycorine; Apoptosis; Interferon; ROS
-
Mandarin Fish Ranavirus (MRV) Infection Induced Inflammation and Histologic Lesions in the Gut of Mandarin Fish
作者:Gao, Xinru;Zhang, Ziye;Li, Yugu;Gao, Xinru;Zhang, Ziye;Ma, Yanping;Hao, Le;Liu, Zhenxing;Gao, Xinru;Zhang, Ziye;Ma, Yanping;Hao, Le;Liu, Zhenxing;Huang, Wen
关键词:histologic lesions; inflammation; mandarin fish ranavirus; pathogenesis
-
Apoptosis in spotted sea bass brain and astroglia-like cell line implies a possible pathogenesis of Lateolabrax maculatus iridovirus infection
作者:Xu, Jingjing;Ma, Yanping;Hao, Le;Liu, Zhenxing;Xu, Jingjing;Ma, Yanping;Hao, Le;Liu, Zhenxing
关键词:
Lateolabrax maculatus ; Iridovirus; Apoptosis; Astroglia-like cell line; Mitochondria; Bax -
Characterization of a membrane Fcγ receptor in largemouth bass (Micropterus saloumoides) and its response to bacterial challenge
作者:Wang, Jingya;Wu, Jing;Li, Yugu;Wang, Jingya;Wu, Jing;Ma, Yanping;Hao, Le;Liu, Zhenxing;Wang, Jingya;Wu, Jing;Ma, Yanping;Hao, Le;Liu, Zhenxing;Huang, Wen
关键词:Membrane; Fc gamma R; Largemouth bass; Nocardia seriolae; Immune response
-
Epigoitrin Exerts in vitro anti-MRV Effect via Activation of Interferon-Stimulated Genes
作者:Tao, Ziqian;Tao, Ziqian;Ma, Yanping;Hao, Le;Jia, Mengyan;Liu, Zhenxing;Ma, Yanping;Hao, Le;Jia, Mengyan;Liu, Zhenxing;Huang, Wen;Tao, Ziqian;Ma, Yanping;Hao, Le;Jia, Mengyan;Huang, Wen;Liu, Zhenxing
关键词:epigoitrin; mandarin fish ranavirus; interferon-stimulated genes
-
MiR-181a Negatively Regulates Claudin-3 to Facilitate Lateolabrax maculatus Iridovirus Replication in Lateolabrax maculatus Astroglia Cells
作者:Ma, Yanping;Xu, Jingjing;Hao, Le;Wang, Gang;Liu, Zhenxing;Ma, Yanping;Xu, Jingjing;Hao, Le;Wang, Gang;Huang, Wen;Liu, Zhenxing;Ma, Yanping;Xu, Jingjing;Hao, Le;Wang, Gang;Liu, Zhenxing;Huang, Wen
关键词:Lateolabrax maculatus iridovirus; Claudin-3; MiR-181a; virus replication