Establishment of six homozygous MHC-B haplotype populations associated with susceptibility to Marek's disease in Chinese specific pathogen-free BWEL chickens

文献类型： 外文期刊

第一作者： Gao, Caixia

作者： Gao, Caixia;Han, Lingxia;Liu, Jiasen;Jiang, Qian;Guo, Dongchun;Qu, Liandong;Han, Jianlin

作者机构：

关键词： Chicken;MHC-B haplotype;Microsatellite marker;Hemagglutination test;Marek's disease;Susceptibility

期刊名称：INFECTION GENETICS AND EVOLUTION （ 影响因子：3.342； 五年影响因子：3.188 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The highly polymorphic chicken major histocompatibility complex (MHC) is associated with different levels of immunologic responses to certain avian pathogens. MHC-B haplotype chickens are an important genetic resource for studying the genetic determination of pathogen resistance and susceptibility. The BWEL chicken population is the only specific pathogen-free (SPF) chickens bred and developed by the State Center of Poultry Genetic Resources of Laboratory Animals in China. In this study, we successfully established six homozygous MHC-B haplotype populations from the BWEL chickens using microsatellite marker technology, named as BW/G(1, 2, 3, 5, 6, 7) lines, and their molecular genotypes were matched to six serologically defined MHC-B haplotypes, B13, B15, B2, B5, B21 and B19, respectively. The sequences of BF genes exons 2 and 3 from four successive generations (F1-F4) of the BW/G(n) lines were completely consistent with those of serologically defined MHC-B haplotypes. Subsequently, six BW/G(n) line specific allo-antisera were prepared by immunization with red blood cells (RBCs) and hemagglutination tests results showed the BW/G(n) SPF chickens could be serologically differentiated. Additionally, susceptibility to Marek's disease (MD) in the BW/G3 (B2 haplotype) and BW/G7 (B19 haplotype) lines were determined by comparing mortality, macroscopic and histopathological lesions, and viral loads in feather pulp. The BW/G7 line showed greater genetic susceptibility to the very virulent MD virus (MDV) strain than the BW/G3 line. The establishment of MHC-B haplotype chicken populations associated with susceptibility to MD will be helpful for studying host immune responses and further developing the more effective vaccines in the context of MHC specificities, and they are also very useful for an understanding of MHC genes architecture and function. (C) 2014 Elsevier B.V. All rights reserved.

分类号： R1

  • 相关文献

[1]Protective efficacy of a novel recombinant Marek's disease virus vector vaccine against infectious bursal disease in chickens with or without maternal antibodies. Li, Kai,Liu, Yongzhen,Zhang, Yanping,Gao, Li,Liu, Changjun,Cui, Hongyu,Qi, Xiaole,Gao, Yulong,Zhong, Li,Wang, Xiaomei.

[2]Chicken gga-miR-103-3p Targets CCNE1 and TFDP2 and Inhibits MDCC-MSB1 Cell Migration. Han, Bo,Lian, Ling,Li, Xin,Zhao, Chunfang,Qu, Lujiang,Yang, Ning,Liu, Changjun,Liu, Changjun. 2016

[3]Chicken gga-miR-130a targets HOXA3 and MDFIC and inhibits Marek's disease lymphoma cell proliferation and migration. Han, Bo,Lian, Ling,Li, Xin,Zhao, Chunfang,Qu, Lujiang,Yang, Ning,Liu, Changjun,Song, Jiuzhou.

[4]Chicken gga-miR-181a targets MYBL1 and shows an inhibitory effect on proliferation of Marek's disease virus-transformed lymphoid cell line. Lian, Ling,Li, Xin,Zhao, Chunfang,Han, Bo,Qu, Lujiang,Yang, Ning,Song, Jiuzhou,Liu, Changjun.

[5]Characterization of Copy Number Variation's Potential Role in Marek's Disease. Xu, Lingyang,He, Yanghua,Ding, Yi,Sun, Guirong,Carrillo, Jose Adrian,Li, Yaokun,Ghaly, Mona M.,Ma, Li,Song, Jiuzhou,Xu, Lingyang,Liu, George E.,Xu, Lingyang,Sun, Guirong,Li, Yaokun,Ghaly, Mona M.,Zhang, Huanmin. 2017

[6]Toxoplasma gondii infection in Bactrian camel (Camelus bactrianus) in China. Wang, M.,Wang, Y. H.,Meng, P.,Ye, Q.,Zhang, D. L..

[7]Gene expression analysis of host spleen responses to Marek's disease virus infection at late tumor transformation phase. Lian, L.,Qu, L. J.,Sun, H. Y.,Chen, Y. M.,Yang, N.,Lamont, S. J.,Liu, C. J.. 2012

[8]Lipoprotein metabolism differs between Marek's disease susceptible and resistant chickens. Yuan, P.,Yu, Y.,Luo, J.,Tian, F.,Song, J.,Yu, Y.,Zhang, H.,Chang, S.,Ramachandran, R.,Zhang, L.. 2012

[9]Expression profiles of genes within a subregion of chicken major histocompatibility complex B in spleen after Marek's disease virus infection. Lian, L.,Qu, L. J.,Zheng, J. X.,Chen, Y. M.,Xu, G. Y.,Yang, N.,Liu, C. J.,Zhang, Y. P.. 2010

[10]Interaction between endoparasitoid &ITMicroplitis mediator&IT (Hymenoptera: Braconidae) and nucleopolyhedrovirus in larvae of &ITHelicoverpa armigera&IT (Lepidoptera: Noctuidae). Lu, Zhenqiang,Li, Zhen,Yang, Yuhui,Zhang, Qingwen,Liu, Xiaoxia,Lu, Ziyun,Li, Jiancheng. 2017

[11]Susceptibility of Chinese Perch Brain (CPB) Cell and Mandarin Fish to Red-Spotted Grouper Nervous Necrosis Virus (RGNNV) Infection. Tu, Jiagang,Chen, Wenjie,Zhao, Lijuan,Lan, Jiangfeng,Lin, Li,Fu, Xiaozhe,Lin, Qiang,Chang, Ouqin,Li, Ningqiu. 2016

[12]Specific MHC class II B alleles associated with resistance to Edwardsiella tarda in turbot, Psetta maxima (L.). Xu, J-Y,Chen, S-L,Ding, H.,Xu, J-Y. 2009

[13]Monitoring of resistance for the diamondback moth to Bacillus thuringiensis Cry1Ac and Cry1Ba toxins and a Bt commercial formulation. Li, X.-F.,Zhang, J.,Zhao, J.-Z.,Wu, Q.-J.,Xu, B.,Zhang, Y.-J.. 2007

[14]MHC polymorphism and disease resistance to vibrio anguillarum in 8 families of half-smooth tongue sole (Cynoglossus semilaevis). Du, Min,Chen, Song-lin,Liu, Yang,Yang, Jing-feng,Du, Min,Du, Min,Liu, Yan-hong. 2011

[15]Effects of cold-hardening on chilling-induced photoinhibition of photosynthesis and on xanthophyll cycle pigments in sweet pepper. Liu, P,Meng, QW,Zou, Q,Zhao, SJ,Liu, QZ.

[16]Comparison of susceptibility of Chilo suppressalis and Bombyx mori to five Bacillus thuringiensis proteins. Yang, Yan,Peng, Yufa,Li, Yunhe,Meissle, Michael.

[17]Changes in antimicrobial resistance among Salmonella enterica subspecies enterica serovar Pullorum isolates in China from 1962 to 2007. Pan, Zhiming,Wang, Xiaoquan,Zhang, Xiaoming,Geng, Shizhong,Chen, Xiang,Pan, Weijuan,Cong, Qiuxia,Jiao, Xinan,Liu, Xiufan,Liu, Xuexian.

[18]Differential fipronil susceptibility and metabolism in two rice stem borers from China. Ye, Gong-Yin,Yao, Hong-Wei,Cheng, Jia-An,Akhtar, Zunnu-Raen,Huang, Cheng-Hua.

[19]SUSCEPTIBILITY AND CARBOXYLESTERASE ACTIVITY OF FIVE FIELD POPULATIONS OF PANONYCHUS CITRI (MCGREGOR) (ACARI: TETRANYCHIDAE) TO FOUR ACARICIDES. Ran, Chun,Chen, Yang,Wang, Jin-Jun,Ran, Chun.

[20]Baseline Susceptibility of Plutella xylostella (Lepidoptera: Plutellidae) to the Novel Insecticide Spinetoram in China. Zhang, Jingming,Zhang, Pengjun,Lin, Wencai,Hang, Fang,Zhang, Zhijun,Lu, Yaobin,Lin, Qingsheng,Li, Zhenyu.

作者其他论文 更多>>

微信小程序