Cytotoxicity and Apoptosis Induction of Bovine Alpha-lactalbumin-oleic Acid Complex in Human Breast Cancer Cells

文献类型： 外文期刊

第一作者： Zhong, Saiyi

作者： Zhong, Saiyi;Chen, Suhua;Zhou, Siyi;Qin, Xiaoming;Wang, Weimin;Liu, Shouchun;Liu, Hai

作者机构：

关键词： bovine alpha-lactalbumin-oleic acid;cytotoxicity;apoptosis;human breast cancer cells

期刊名称：FOOD SCIENCE AND TECHNOLOGY RESEARCH （ 影响因子：0.668； 五年影响因子：0.895 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Breast cancer is the mostly commonly diagnosed cancer in women worldwide. Using food-based approach to breast cancer chemoprevention has attracted a great deal of attention in recent years. In the present study, a-lactalbumin was purified from fresh bovine milk and the complex with oleic acid (BLA-OA Complex) was prepared by chromatographic method. The cytotoxic and apoptotic activities of BLA-OA complex on human ERpositive MCF-7 and ER-negative MDA-MB-231 breast cancer cells was investigated by morphological observation, MTS assay, LDH release, DAPI staining, DNA ladder assay and cell cycle analysis. The results showed that BLA-OA complex inhibits cells growth and induces apoptosis in both human ER-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cell lines. The findings of this study are positive for cow milk industry and human breast cancer chemoprevention.

分类号： TS2

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