Flaxseed oil containing flaxseed oil ester of plant sterol attenuates high-fat diet-induced hepatic steatosis in apolipoprotein-E knockout mice

文献类型： 外文期刊

第一作者： Han, Hao

作者： Han, Hao;Ma, Hongfei;Rong, Shuang;Chen, Li;Shan, Zhilei;Liu, Liegang;Han, Hao;Ma, Hongfei;Rong, Shuang;Chen, Li;Shan, Zhilei;Liu, Liegang;Xu, Jiqu;Zhang, Yunjian

作者机构：

关键词： Hepatic steatosis;Flaxseed oil ester of plant sterols;Lipid metabolism;Oxidative stress;Inflammation

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： The prevalence of non-alcoholic fatty liver disease (NAFLD) has dramatically increased globally during recent decades. Dietary flaxseed oil and plant sterol exert potential benefit to NAFLD. Present study was designed to evaluate the effects of flaxseed oil containing flaxseed oil ester of plant sterols (FO-PS) on hepatic steatosis induced by high fat diet (HFD) and investigate the underlying molecular mechanisms. C57BL/6 mice were administered a regular diet (RG) and apoE-/- mice were given HFD alone or plus 5% flaxseed oil with or without 3.3% FO-PS for 18 weeks. Our data showed that HFD induced NAFLD while dietary flaxseed oil fortified with FO-PS offered a synergistically effective strategy for improving hepatic steatosis as well as optimizing overall lipid levels, reducing oxidative stress and inhibiting system inflammation. The expression levels of hepatic genes involved in cholesterol efflux (ABCA1, LXR, SR-BI) and triacylglycerol catabolism (PPAR alpha) were also increased significantly by intervention of flaxseed oil plus FO-PS. In addition, combination treatment reduced ROS production and down-regulated inflammatory markers (IL-6, TNF, MCP-1 and ICAM-1) in liver. Thus, dietary supplementation of flaxseed oil containing FO-PS altered the expressions of genes related to lipid metabolism and inflammation, and thus ameliorated hepatic steatosis. (C) 2014 Elsevier Ltd. All rights reserved.

分类号： TS2

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