Mutant Rep protein of the porcine circovirus type 2 N-glycosylation:23-25aa, 256-258aa mutation reduced virus replication but 286-288aa mutation enhanced virus replication in PK-15 cells

文献类型: 外文期刊

第一作者: Shi, Jianli

作者: Shi, Jianli;Peng, Zhe;Xu, Shaojian;Cong, Xiaoyan;Yuan, Xiaoyuan;Yu, Jiang;Wu, Jiaqiang;Sun, Wenbo;Du, Yijun;Li, Jun;Wang, Jinbao;Fu, Fang;Xu, Shengnan

作者机构:

关键词: Porcine circovirus type 2;N-Glycosylation;Mutationat;Infectious clone;Rescued

期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.293; 五年影响因子:3.599 )

ISSN:

年卷期:

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收录情况: SCI

摘要: Porcine circovirus type 2 (PCV2) Rep protein and the splice variant Rep' protein impact genome replication. The Rep protein contains three potential N-glycosylation at positions 23-25aa (NPS), 256-258aa (NQT) and 286-288aa (NAT). Three double copy infectious clones with Rep protein N-glycosylation at positions mutations 23-25aa (DPS), 256-258aa (DQT) and 286-288aa (DAT) were constructed and their function in virus replication in PK-15 cells was investigated. The results showed that the double copy infectious clone with N-glycosylation site mutation could be rescued in vitro and 23-25aa, 256-258aa mutation reduced virus replication but 286-288aa mutation enhanced virus replication. (C) 2015 Elsevier B.V. All rights reserved.

分类号: S8

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