Nanostructured calcium phosphate carriers for deliver of poor water-soluble drug silybin

文献类型： 外文期刊

第一作者： Chen, Lei

作者： Chen, Lei;Zhu, Hualing;Yang, Song;Zhou, Beibei;You, Fenghui;Yan, Xiaoming

作者机构：

关键词： Biomaterials;Nanocrystalline materials;Silybin;Calcium phosphate;Drug delivery

期刊名称：MATERIALS LETTERS （ 影响因子：3.423； 五年影响因子：3.003 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Silybin, the main component of silymarin, has been widely used as a hepatoprotective agent for a variety of acute and chronic liver diseases. However, its poor aqueous solubility lead to poor oral absorption and low bioavailability, which strongly limit its applications. The amorphous calcium phosphate (ACP) nanosphere and hydroxyapatite (HAP) nanorod have been prepared and used for the investigation of the silybin loading and release. The results indicate that both ACP nanosphere and HAP nanorod have relatively high silybin-loading capacities which reach to 900 and 825 mg.g(-1). Moreover, the as-prepared silybin delivery systems exhibit sustained drug release performance in simulated gastric fluid and simulated intestinal fluid. (C) 2015 Elsevier B.V. All rights reserved.

分类号： TB1`TB3

  • 相关文献

[1]UV-Initiated Copolymerization Route for Facile Fabrication of Epoxy-Functionalized Micro-Zone Plates. Li, Li,Feng, Min,Zhu, Jia-Ting,Bi, Xiao-Dong. 2014

[2]Selective synthesis of Fe3O4AuxAgy nanomaterials and their potential applications in catalysis and nanomedicine. Fodjo, Essy Kouadio,Serge, Brou Yapi,Trokourey, Albert,Gabriel, Koffi Mouroufie,Li, Dan,Kong, Cong. 2017

[3]Foot-and-mouth disease virus-like particles as integrin-based drug delivery system achieve targeting anti-tumor efficacy. Yan, Dan,Teng, Zhidong,Sun, Shiqi,Dong, Hu,Gao, Yuan,Wei, Yanquan,Liu, Xiangtao,Yin, Hong,Guo, Huichen,Yan, Dan,Teng, Zhidong,Sun, Shiqi,Dong, Hu,Gao, Yuan,Wei, Yanquan,Liu, Xiangtao,Yin, Hong,Guo, Huichen,Jiang, Shan,Qin, Wenwu. 2017

[4]Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon. Li, Puwang,Yang, Ziming,Peng, Zheng,Li, Sidong,Kong, Lingxue,Wang, Qinghuang,Wang, Yichao,Kong, Lingxue,Wang, Qinghuang. 2015

[5]Cutting Edge Protein and Carbohydrate-Based Materials for Anticancer Drug Delivery. Ahmad, Rasheed,Deng, Yan,Hussain, Mubashir,He, Nongyue,Ahmad, Rasheed,Sun, Yueming,Shah, Muhammad Ali Abdullah,Singh, Ravina,Elingarami, Sauli,Deng, Yan,He, Nongyue. 2018

[6]The application of virus-like particles as vaccines and biological vehicles. Yan, Dan,Wei, Yan-Quan,Guo, Hui-Chen,Sun, Shi-Qi,Yan, Dan,Wei, Yan-Quan,Guo, Hui-Chen,Sun, Shi-Qi.

[7]Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer. Wang, Yichao,Wang, Yichao,Li, Puwang,Thao Truong-Dinh Tran,Zhang, Juan,Kong, Lingxue,Li, Puwang,Thao Truong-Dinh Tran. 2016

[8]Nanogels fabricated by lysozyme and sodium carboxymethyl cellulose for 5-fluorouracil controlled release. Zhu, Kunkun,Ye, Ting,Liu, Jinjin,Xu, Shasha,Lei, Jieqiong,Deng, Hongbing,Li, Bin,Zhu, Kunkun,Ye, Ting,Liu, Jinjin,Xu, Shasha,Lei, Jieqiong,Deng, Hongbing,Li, Bin,Zhu, Kunkun,Peng, Zheng.

作者其他论文 更多>>
  • Dynamics of water status during fruiting body development of Agaricus bisporus and its relationship to mushroom quality

    作者：Wan, Lingzhong;Sun, Hui;Ni, Ying;Wu, Juan;Yan, Xiaoming;Deng, Xiaonan;Tang, Jun;Yu, Junjie

    关键词：Water status; Low-field nuclear magnetic resonance (LF-NMR); Agaricus bisporus; Fruiting body; Textural quality

  • The beetle's structural protein CPCFC making elytra tough and rigid

    作者：Bao, Han;Liu, Yuantao;Yang, Qing;Duan, Yanwei;Chen, Lei;Yang, Qing;Yang, Qing

    关键词：biomaterial; chitin hydrogel; CPCFC; insect cuticle

  • QTL-based dissection of three key quality attributes in maize using double haploid populations

    作者：He, Zitian;Li, Jianwei;Wang, Jianping;Zhang, Xiaolei;Wang, Jianping;Zhang, Xiaolei;Li, Jialei;Chen, Lei

    关键词：maize; starch; oil; lysine; QTLs; genetic analysis

  • Nanoporous Zeolite Anchored Cellulose Nanofiber Aerogel for Safe and Efficient Hemostasis

    作者：Chen, Lei;Jin, Zhiping;Kamiya, Takumi;Liu, Xiaodi;Tian, Yichen;Xia, Ruicai;Zhang, Qiang;Wang, Guodong;Li, Tao

    关键词：cellulose nanofiber aerogel; hemostasis; low loading ratio; nanoporous zeolite; tightly bonding

  • EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research

    作者：Bai, Defeng;Xun, Jiani;Ma, Chuang;Luo, Hao;Yang, Haifei;Hou, Huiyu;Lv, Hujie;Wan, Xiulin;Wang, Yao;Yousuf, Salsabeel;Zeng, Meiyin;Zhang, Tianyuan;Gao, Yunyun;Liu, Yong-Xin;Chen, Tong;Ma, Chuang;Yang, Haifei;Cao, Chen;Cao, Xiaofeng;Cui, Jianzhou;Deng, Yuan-Ping;Deng, Zhaochao;Yu, Hao;Zhang, Chunfang;Dong, Wenxin;Dong, Wenxue;Du, Juan;Fang, Qunkai;Fang, Wei;Fang, Yue;Luan, Yaning;Fu, Fangtian;Fu, Min;Fu, Yi-Tian;Gao, He;Ge, Jingping;Guo, Yuhao;Gong, Qinglong;Lou, Wenbo;Gu, Lunda;Yang, Li;Guo, Peng;Hai, Tang;Liu, Hao;He, Jieqiang;He, Zi-Yang;Huang, Can;Ji, Shuai;Jiang, ChangHai;Jiang, Gui-Lai;Jiang, Lingjuan;Jin, Ling N.;Li, Changchao;Kan, Yuhe;Kang, Da;Kou, Jin;Lam, Ka-Lung;Li, Chong;Li, Fuyi;Li, Liwei;Li, Miao;Li, Xin;Li, Ye;Li, Zheng-Tao;Zhu, Chengshuai;Liang, Jing;Mo, Jiayuan;Lin, Yongxin;Liu, Changzhen;Liu, Danni;Zhang, Jing;Chen, Shifu;Liu, Fengqin;Liu, Jia;Liu, Tianrui;Liu, Tingting;Wang, Xinlong;Liu, Xinyuan;Luo, Yuanyuan;Liu, Yaqun;Liu, Bangyan;Liu, Minghao;Lv, Hujie;Ma, Tengfei;Mai, Zongjiong;Niu, Dongze;Pan, Zhuo;Qi, Heyuan;Shi, Zhanyao;Song, Chunjiao;Sun, Fuxiang;Sun, Yan;Tian, Sihui;Wang, Guoliang;Wang, Hongyang;Wang, Hongyu;Wang, Huanhuan;Wang, Jing;Wang, Jun;Wang, Kang;Wang, Leli;Yao, Xiaofang;Wang, Shao-kun;Xiao, Zufei;Xing, Huichun;Xu, Yifan;Yang, Song;Yan, Shu-yan;Zhang, Yi-Bo;Yang, Yuanming;Lei, Yu;Yuan, Zhengrong;Zhang, Chunge;Zhang, Huimin;Zhang, Na;Zhang, Yupeng;Zhang, Zheng;Zhou, Mingda;Zhou, Yuanping;Zhu, Zhihao;Zhu, Lin;Zhu, Yue;Zou, Hongqin;Zuo, Anna;Dong, Wenxuan;Wen, Tao;Chen, Shifu;Chen, Shifu;Li, Guoliang

    关键词：metagenome; microbiome; microbiota; pipeline; visualization

  • Natural UV protectants and humectants to improve the efficiency of Steinernema carpocapsae in controlling foliar pests

    作者：Ha, Bingjun;Wei, Xianqin;Lu, Peiyu;Qing, Hui;Guo, Jinxuan;Chen, Lei;Ruan, Weibin;Zhang, Renjia;Li, Xingyue;Hu, Bin;Wang, Shuaiyu;Xu, Yang;Fu, Zhen;Shapiro-Ilan, David

    关键词：foliar application; formulation; ultraviolet radiation; leaf herbivore; Steinernema carpocapsae; biological control

  • Multifunctional Role of Cytokinin in Horticultural Crops

    作者：Hussain, Shahid;Chang, Jingjing;Li, Jing;Chen, Lei;Song, Zhao;Zhang, Baige;Chen, Xiao;Ahmad, Sheraz

    关键词：cytokinin; flowering; fruit setting; stress biology; physiology

微信小程序