Identification of amino-acid residues in the V protein of peste des petits ruminants essential for interference and suppression of STAT-mediated interferon signaling

文献类型： 外文期刊

第一作者： Ma, Xusheng

作者： Ma, Xusheng;Yang, Xing;Zhang, Zhidong;Dou, Yongxi;Luo, Xuenong;Su, Junhong;Zhu, Qiyun;Cai, Xuepeng;Nian, Xiaofeng;Zhang, Xuehu

作者机构：

关键词： PPRV;V protein;IFN;STAT1;STAT2

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

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收录情况： SCI

摘要： Peste des petits ruminants virus (PPRV) causes a fatal disease in small ruminants. V protein of PPRV plays a pivotal role in interfering with host innate immunity by blocking IFNs signaling through interacting with STAT1 and STAT2. In the present study, the results demonstrated that PPRV V protein blocks IFN actions in a dose dependent manner and restrains the translocation of STAT1/2 proteins. We speculate that the translocation inhibition might be caused by the interfering of the downstream of STAT protein. Mutagenesis defines that Cys cluster and Trp motif of PPRV V protein are essential for STAT-mediated IFN signaling. These findings give a new sight for the further studies to understand the delicate mechanism of PPRV to escape the IFN signaling. (C) 2015 Elsevier Inc. All rights reserved.

分类号： R37

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