Production and optimization of monacolin K by citrinin-free Monascus pilosus MS-1 in solid-state fermentation using non-glutinous rice and soybean flours as substrate

文献类型： 外文期刊

第一作者： Feng, Yanli

作者： Feng, Yanli;Shao, Yanchun;Chen, Fusheng;Feng, Yanli;Shao, Yanchun;Chen, Fusheng;Zhou, Youxiang

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关键词： Monascus pilosus MS-1;Monacolin K;Citrinin-free;Box-Behnken design;Solid-state fermentation

期刊名称：EUROPEAN FOOD RESEARCH AND TECHNOLOGY （ 影响因子：2.998； 五年影响因子：3.005 ）

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收录情况： SCI

摘要： Monacolin K (MK) acts as a natural inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Red fermented rice by Monascus spp. which is rich in MK can be used as dietary supplement to reduce the serum triglyceride and total cholesterol. A Monascus pilosus MS-1 with high-producing MK but free of citrinin had been screened in our previous investigation. Here, its solid-state fermentation parameters were optimized using statistical methods to maximize MK yield when non-glutinous rice and soybean flours were used as substrate. Maximum MK yield (17.662 mg/g) was predicted when 55 g dry substrate (20 sieve mesh), including 60 % non-glutinous rice flour and 40 % soybean flour, was put into a 250-mL conical flask, and the contents of water, acetic acid and MgSO4 center dot 7H(2)O were adjusted to 35 %, 0.6 % (v/w) and 0.004 mol/kg, respectively. Then, the substrate was mixed and sterilized, and scattered before cooling. Later, 13 % (v/w) inoculum pre-cultured for 36 h at 30 A degrees C was used, then incubated at 30 A degrees C for 60 h and followed by a further incubation at 24 A degrees C up to 14 days. The verified MK yield was 18.733 mg/g, which was 106.06 % to the predicted MK yield. The MK yield was enhanced to 33 times after optimization. No citrinin was detected in Monascus pilosus MS-1 fermented products. These results indicate that citrinin-free MK can be produced under the optimized conditions.

分类号： R15

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