Immunoregulatory and antitumor activity of schizophyllan under ultrasonic treatment

文献类型： 外文期刊

第一作者： Zhong, Kui

作者： Zhong, Kui;Tong, Litao;Liu, Liya;Zhou, Xianrong;Liu, Xingxun;Zhang, Qi;Zhou, Sumei;Zhong, Kui;Tong, Litao;Liu, Liya;Zhou, Xianrong;Liu, Xingxun;Zhang, Qi;Zhou, Sumei

作者机构：

关键词： Schizophyllan (SPG);Ultrasonic treatment;Immunoregulatory activity;Antitumor activity

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Aim of this study was to investigate the effect of ultrasonic treatment on the biological activities of schizophyllan (SPG) from Schizophyllum commune. The immunoregulatory and antitumor activity in vitro and in vivo of SPG and ultrasonic-treated SPG (USPG) were evaluated by splenic lymphocytes, macrophages RAW264.7 and human breast carcinoma T-47D cells. Compared with SPG, USPG fractions had small molecular weight and narrow distribution. Meantime, more enhancement of NO production in macrophages RAW264.7, lymphocytes proliferation rates, IL-2 and TNF-alpha level from spleen lymphocytes and T-47D cells inhibition rates were observed in USPG fractions groups. This result indicated that the immune-enhancing and antitumor activity of SPG was significantly improved after ultrasonic treatment. USPG60 exhibited the highest biological activity in this study. In conclusion, application of ultrasonic technology on SPG preparation is an efficient approach to get high biological polysaccharide, and USPG60 might be a potential functional component for immunoregulatory and cancer treatment. (C) 2015 Elsevier B.V. All rights reserved.

分类号： Q71

  • 相关文献

[1]Use of ultrasonic and pepsin treatment in tandem for collagen extraction from meat industry by-products. Ran, Xue-Guang,Ran, Xue-Guang,Ran, Xue-Guang,Ran, Xue-Guang,Wang, Ling-Yun. 2014

[2]Optimization of postharvest ultrasonic treatment of strawberry fruit. Cao, Shifeng,Hu, Zhichao,Pang, Bin. 2010

[3]Influence of ultrasonic treatment on the structure and emulsifying properties of peanut protein isolate. Zhang, Qiu-Ting,Tu, Zong-Cai,Liu, Cheng-Mei,Shi, Yan,Fan, Liang-Liang,Tu, Zong-Cai,Huang, Xiao-Qin,Xiao, Hui,Wang, Hui,Liu, Guang-Xian,Wang, Hui,Lin, De-Rong. 2014

[4]Molecular weight degradation and rheological properties of schizophyllan under ultrasonic treatment. Zhou, Sumei.

[5]Effect of nutritional and environmental conditions on the production of exo-polysaccharide of Agaricus brasiliensis by submerged fermentation and its antitumor activity. Fan, Leifa,Soccol, Andrea Thomaz,Pandey, Ashok,Soccol, Carlos Ricardo. 2007

[6]Optimization of Enzyme-assisted Extraction of Antitumor Polysaccharides from Hericium erinaceus mycelia. Qin, Yi,Zhang, Zuofa,Song, Tingting,Lv, Guoying.

[7]Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents. Ke, Shaoyong,Shi, Liqiao,Yang, Ziwen.

[8]Design, Synthesis and Bioactivity of N-Glycosyl-N '-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives. Cui, Zining,Nishida, Yoshihiro,Su, Hang,Jiang, Jiazhen,Yang, Xinling,Cui, Zining. 2014

[9]Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety. Cui, Zining,Dohi, Hirofumi,Nishida, Yoshihiro,Cui, Zining,Yang, Xinling,Shi, Yanxia,Uzawa, Hirotaka,Cui, Jingrong. 2011

[10]Antioxidant and Cytotoxic Activities of Ethanolic Extracts and Isolated Fractions of Species of the Genus Phellinus Quel. (Aphyllophoromycetideae). Yang, Yan,Hu, Jinxia,Liu, Yanfang,Feng, Na,Chen, Hui,Tang, Qingjiu,Zhang, Jingsong,Ye, LinBin. 2011

[11]Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan. Cui, Zi-Ning,Ling, Yun,Yang, Xin-Ling,Shi, Yan-Xia,Li, Bao-Ju,Cui, Jing-Rong. 2012

[12]A novel antibiotic produced by streptomyces noursei Da07210. Wu, Xiaopeng,Huang, Huiqin,Sun, Qianguang,Peng, Jie,Zhu, Jun,Bao, Shixiang,Chen, Guangying. 2009

[13]Synthesis and in vitro antitumor activity of (1E, 4E)-1-aryl-5-(2-(( quinazolin-4-yl) oxy) phenyl)-1,4-pentadien-3-one derivatives. Luo, Hui,Xie, Pu,Yang, Shengjie,Hong, Da,Luo, Hui,Yang, Shengjie,Xue, Wei,Luo, Hui,Yang, Shengjie,Xue, Wei. 2017

[14]Chemical Characterization of a Procyanidin-Rich Extract from Sorghum Bran and Its Effect on Oxidative Stress and Tumor Inhibition in Vivo. Wu, Li,Huang, Zhaohui,Qin, Peiyou,Yao, Yang,Ren, Guixing,Huang, Zhaohui,Meng, Xianjun,Zou, Jianqiu,Zhu, Kai.

[15]Synthesis and biological activities of 2-oxocycloalkylsulfonamides. Yang, Xinling,Liang, Xiaomei,Kai, Zhenpeng,Yuan, Dekai,Zhang, Jianjun,Ling, Yun,Chen, Fuheng,Wang, Daoquan,Yuan, Huizu,Qi, Shuhua,Wang, Ruiqing,Ran, Fuxiang. 2008

[16]Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan. Li, Xinghai,Cui, Zining,Nishida, Yoshihiro,Cui, Zining. 2014

[17]Synthesis, antitumor activity and mechanism of action of novel 1,3-thiazole derivatives containing hydrazide-hydrazone and carboxamide moiety. He, Haifeng,Wang, Xiaoyan,He, Hongwu,Shi, Liqiao,Yin, Wenyan,Yang, Ziwen,Liang, Ying. 2016

[18]Synthesis of Novel Steroid Derivatives Derived from Dehydroepiandrosterone as Potential Anticancer Agents. Ke, Shaoyong,Shi, Liqiao,Yang, Qingyu,Yang, Ziwen,Wei, Yanhong,Yang, Ziwen. 2013

[19]Antitumor Compounds from the Stout Camphor Mushroom Taiwanofungus camphoratus (Higher Basidiomycetes) Spent Culture Broth. Jia, Wei,Bai, Yan-Yan,Zhang, Zhong,Feng, Na,Feng, Jie,Yan, Meng-Qiu,Zhu, Li-Na,Zhang, Jing-Song,Fan, Hua,Bai, Yan-Yan,Jia, Xin-Cheng,Wang, Ming-Dao,Fan, Hua.

[20]Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation. Shi, Liqiao,Hui, Rui,Wei, Yanhong,Liang, Ying,Yang, Ziwen,Ke, Shaoyong.

作者其他论文 更多>>

微信小程序