Mutations in and Expression of the Tumor Suppressor Gene p53 in Egg-Type Chickens Infected With Subgroup J Avian Leukosis Virus

文献类型： 外文期刊

第一作者： Yue, Q.

作者： Yue, Q.;Yulong, G.;Liting, Q.;Shuai, Y.;Delong, L.;Xiaomei, W.;Yue, Q.;Lili, J.;Delong, L.;Sidang, L.;Yue, Q.;Yubao, L.;Xiaomei, W.

作者机构：

关键词： subgroup J avian leukosis;egg-type chicken;tumor suppressor gene p53;mutation;retroviruses

期刊名称：VETERINARY PATHOLOGY （ 影响因子：2.221； 五年影响因子：2.834 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： To investigate the molecular mechanisms of the oncogenic effects of avian leukosis virus subgroup J (ALV-J), we examined mutations in and the expression of p53 in the myelocytomas distributed in the liver, spleen, trachea, and bone marrow, as well as in fibrosarcomas in the abdominal cavity and hemangiomas in skin from chickens that were naturally or experimentally infected with ALV-J. Two types of mutations in the p53 gene were detected in myelocytomas of both the experimentally infected and the naturally infected chickens and included point mutations and deletions. Two of the point mutations have not been reported previously. Partial complementary DNA clones with a 122-bp deletion in the p53 gene ORF and a 15-bp deletion in the C-terminus were identified in the myelocytomas. In addition, moderate expression of the mutant p53 protein was detected in the myelocytomas that were distributed in the liver, trachea, spleen, and bone marrow. Mutant p53 protein was not detected in the subcutaneous hemangiomas or in the abdominal fibrosarcomas associated with natural and experimental ALV-J infection, respectively. These results identify mutations associated with abnormal expression of p53 in ALV-J-associated myelocytomas, suggesting a role in tumorigenesis.

分类号： S8

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