Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons
文献类型: 外文期刊
第一作者: Li, Liwei
作者: Li, Liwei;Zhou, Yanjun;Gao, Fei;Jiang, Yifeng;Yu, Lingxue;Zheng, Hao;Tong, Wu;Yang, Shen;Zheng, Haihong;Shan, Tongling;Liu, Fei;Xia, Tianqi;Tong, Guangzhi;Wei, Zuzhang;Zhou, Yanjun;Gao, Fei;Tong, Guangzhi
作者机构:
关键词: miR-26a;PRRSV;Type I interferon;Virus replication
期刊名称:VIRUS RESEARCH ( 影响因子:3.303; 五年影响因子:3.445 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: MicroRNAs (miRNAs) play important roles in viral infections, especially by modulating the expression of cellular factors essential to viral replication or the host innate immune response to infection. To identify host miRNAs important to controlling porcine reproductive and respiratory syndrome virus (PRRSV) infection, we screened 15 miRNAs that were previously implicated in innate immunity or antiviral functions. Over-expression of the miR-26 family strongly inhibited PRRSV replication in vitro, as shown by virus titer assays, Western blotting, and qRT-PCR assays. MiR-26a inhibited the replication of both type 1 and type 2 PRRSV strains. Mutating the seed region of miR-26 restored viral titers. Luciferase reporters showed that miR-26a does not target the PRRSV genome directly but instead affects the expression of type I interferon and the IFN-stimulated genes MX1 and ISG15 during PRRSV infection. These results demonstrate the important role of miR-26a in modulating PRRSV infection and also support the possibility of using host miR-26a to achieve RNAi-mediated antiviral therapeutic strategies. (C) 2014 Elsevier B.V. All rights reserved.
分类号: R37
- 相关文献
作者其他论文 更多>>
-
Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences
作者:Li, Liwei;Chen, Jinxia;Cao, Zhengda;Guo, Ziqiang;Liu, Jiachen;Zhou, Yanjun;Tong, Guangzhi;Gao, Fei;Chen, Jinxia;Tong, Guangzhi;Gao, Fei
关键词:RNA recombination; porcine reproductive and respiratory syndrome virus (PRRSV); transcriptional regulatory sequence (TRS); recombination-resistant; vaccine redesign
-
Variation in microbial communities and network ecological clusters driven by soil organic carbon in an inshore saline soil amended with hydrochar in Yellow River Delta, China
作者:Yao, Hui;Cheng, Yadong;Kong, Qingxian;Wang, Xiao;You, Xiangwei;Li, Yiqiang;Yao, Hui;Cheng, Yadong;Wang, Xiao;You, Xiangwei;Li, Yiqiang;Rong, Ziguo;Quan, Yue;Zheng, Hao
关键词:Soil carbon; Hydrochar; Soil microorganism; Ecological cluster; Coastal salt-affected soil; Soil health
-
Japanese encephalitis virus NS3 captures the protein translation element by interacting with HNRNPH1 to promote viral replication
作者:Wang, Xingya;Li, Lin;Liu, Xuelan;Wang, Xingya;Kong, Ning;Wang, Chen;Qin, Wenzhen;Yang, Xinyu;Yu, Hai;Tong, Wu;Tong, Guangzhi;Zheng, Hao;Shan, Tongling;Kong, Ning;Yu, Hai;Tong, Wu;Tong, Guangzhi;Zheng, Hao;Shan, Tongling;Liu, Xuelan
关键词:JEV; NS3; HNRNPH1; Translation regulation element
-
Effect of myosin-kappa carrageenan pickering emulsions on the quality of bighead carp surimi gels
作者:Ren, Zhongyang;Huang, Xianglan;Shi, Linfan;Yang, Shen;Jin, Ritian;Lin, Rong;Zhang, Yucang;Weng, Wuyin;Zhao, Yongqiang;Liu, Shuji;Liu, Zhiyu;Zhao, Yongqiang
关键词:Kappa carrageenan; Myosin; Pickering emulsions; Aristichthys nobilis; Surimi
-
Cu0-Functionalized, ZIF-8-Derived, Nitrogen-Doped Carbon Composites for Efficient Iodine Elimination in Solution
作者:Chen, Jiuyu;Gao, Chensheng;Liu, Zhiwen;Chen, Jingwen;Liu, Fei
关键词:ZIF-8; Cu-0 nanoparticles; iodine; adsorption; DFT studies
-
A New Method for Constructing High-Resolution Phylogenomic Topologies Using Core Gene-Associated MNP Markers: A Case Study From Agaricus bisporus
作者:Liu, Fei;Zhao, Rui-Lin;Cai, Zhi-Xin;Chen, Wen-Zhi;Lu, Yuan-Ping;Chen, Mei-Yuan;Kang, Wen-Yi;Zhao, Rui-Lin
关键词:core gene-associated MNP markers; fungal species; phylogenetic tree; strain identification
-
Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact
作者:Liu, Liuqingqing;Li, Xinyao;Luo, Xianxiang;Liu, Linjia;Yuan, Zixi;Sun, Cuizhu;Zheng, Hao;Li, Fengmin;Luo, Xianxiang;Zheng, Hao;Li, Fengmin;Wang, Xiao;Xu, Elvis Genbo
关键词:Endocrine disrupting chemicals; Neurotoxicity; Brain-gut axis; Anxiety behavior; Gut microbiome; Behavioral ecology