Insulin-Like Growth Factor Binding Protein-2 Promotes Adhesion of Endothelial Progenitor Cells to Endothelial Cells via Integrin alpha 5 beta 1

文献类型： 外文期刊

第一作者： Feng, Nianping

作者： Feng, Nianping;Zhang, Zhuo;He, Xijun;Wang, Chunlai;Wang, Zhengfei;Zheng, Haihong;Qu, Fujun

作者机构：

关键词： Neovascularization;Endothelial progenitor cell;IGF binding protein 2;Integrin;RGD motif

期刊名称：JOURNAL OF MOLECULAR NEUROSCIENCE （ 影响因子：3.444； 五年影响因子：3.129 ）

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收录情况： SCI

摘要： The contribution of endothelial progenitor cells (EPCs) to new vessel formation has been studied in different physiological and pathological conditions for decades. As previously suggested, insulin-like growth factor binding protein-2 (IGFBP-2) may interact with integrins and promote cell migration. However, the role of IGFBP-2 in regulation of EPC functions remains largely unknown. In this present study, we found that overexpression of IGFBP-2 in human umbilical vein endothelial cells (HUVECs) promoted EPC-endothelial adhesion. Conversely, siRNA-mediated depletion of IGFBP-2 inhibited oxygen-glucose deprivation (OGD)-induced EPC-endothelial adhesion. Further, we demonstrated that the arginine-glycine-aspartic acid (RGD) motif in its C-domain is required for interaction with integrin alpha 5 beta 1. In addition, treatment with IGFBP-2 significantly enhanced incorporation of EPCs into tubule networks formed by HUVECs. Thus, our findings suggest that exogenous administration of IGFBP-2 may facilitate neovascularization and improve treatment of ischemic conditions.

分类号： Q4

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