H5N1 influenza virus-like particle vaccine protects mice from heterologous virus challenge better than whole inactivated virus

文献类型: 外文期刊

第一作者: Ren, Zhiguang

作者: Ren, Zhiguang;Qin, Chuan;Xia, Xianzhu;Ren, Zhiguang;Qin, Chuan;Xia, Xianzhu;Ren, Zhiguang;Ji, Xianliang;Meng, Lingnan;Wei, Yurong;Wang, Tiecheng;Feng, Na;Zheng, Xuexing;Wang, Hualei;Li, Nan;Gao, Xiaolong;Zhao, Yongkun;Yang, Songtao;Gao, Yuwei;Xia, Xianzhu;Ji, Xianliang;Meng, Lingnan;Wei, Yurong;Jin, Hongli;Gao, Yuwei;Xia, Xianzhu;Gao, Yuwei;Xia, Xianzhu

作者机构:

关键词: H5N1 influenza;Protection;Virus-like particles;Vaccine;Cross-protective

期刊名称:VIRUS RESEARCH ( 影响因子:3.303; 五年影响因子:3.445 )

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收录情况: SCI

摘要: The highly pathogenic avian influenza (HPAI) H5N1 virus has become highly enzootic since 2003 and has dynamically evolved to undergo substantial evolution. Clades 2.3.2.1 and 2.3.4 have become the most dominant lineage in recent years, and H5N8 avian influenza outbreaks have been reported Asia. The current approach to generate influenza virus vaccines uses embryonated chicken eggs for large-scale production, although such vaccines have been poorly immunogenic to heterologous virus challenge. In the current study, virus-like particles (VLP) based on A/meerkat/Shanghai/SH-1/2012 (clade 23.2.1) and comprising hemagglutinin (HA), neuraminidase (NA), and matrix (M1) were produced using a baculovirus expression system to develop effective protection for different H5 HPAI clade challenges. Mice immunized with VLP demonstrated stronger humoral and cellular immune responses than mice immunized with whole influenza virus (WIV), with 20-fold higher IgG antibody titers against A/meerkat/Shanghai/SH-1/2012 after boost. Notably, the WIV vaccine group showed partial protection (80% survival) to homologous challenge, little protection (40% survival) to heterologous challenge, and 20% survival to H5N8 challenge, whereas all mice in the VLP + CFA group survived. These results provide insight for the development of effective prophylactic vaccines based on VLPs with cross-clade protection for the control of current H5 HPAI outbreaks in humans. (C) 2015 Elsevier B.V. All rights reserved.

分类号: R37

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