Bioactive compounds from Pu-erh tea with therapy for hyperlipidaemia

文献类型： 外文期刊

第一作者： Lv, Hai-Peng

作者： Lv, Hai-Peng;Zhu, Yin;Tan, Jun-Feng;Guo, Li;Dai, Wei-Dong;Lin, Zhi

作者机构：

关键词： Pu-erh tea;Hypolipidaemic effect;Transcriptional regulation;Bioactive compounds;Flavonoids

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： In this study, successive extractions of the Pu-erh tea were performed utilising water, chloroform, ethyl acetate, and n-butanol. The different extracts were investigated for regulation of transcription factors involved in lipid metabolism including Farnesoid X Receptor (FXR), Liver X-activated Receptor (LXR), and the Peroxisome Proliferator-Activated Receptor (PPAR, and PPAR(delta)) using reporter gene assays. The data indicated that the ethyl acetate extract had the strongest activation potential for FXR and PPAR(delta), and Fraction 6 from the ethyl acetate extract obtained by column chromatography had the highest hypolipidaemic potential. Further chromatographic separation of Fraction 6 led to the isolation of 7 flavonoids, and their contents varied between 7.6 and 51.8 mg/g. Additionally, sixty-four chemical constituents were identified from Fraction 6 by UPLC-MS/MS and their relative amounts were determined by the ion intensity. These results showed that the flavonoids were the major bioactive compounds in Pu-erh tea responsible for its hypolipidaemic effects. (C) 2015 Elsevier Ltd. All rights reserved.

分类号： TS2

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