Anti-inflammatory effects of 4 '-demethylnobiletin, a major metabolite of nobiletin
文献类型: 外文期刊
第一作者: Wu, Xian
作者: Wu, Xian;Song, Mingyue;Rakariyatham, Kanyasiri;Zheng, Jinkai;Guo, Shanshan;Xiao, Hang;Zheng, Jinkai;Guo, Shanshan;Tang, Zhonghai;Zhou, Shuangde;Xiao, Hang
作者机构:
关键词: 4 '-Demethylnobiletin;Nobiletin;Anti-inflammation;NF-kappa B;Nrf2;Metabolites
期刊名称:JOURNAL OF FUNCTIONAL FOODS ( 影响因子:4.451; 五年影响因子:4.907 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Nobiletin, a citrus flavonoid, has been associated with various beneficial biological activities. 4'-Demethylnobiletin (4DN) is a major metabolite of nobiletin, and its tissue level was found to be much higher than that of nobiletin after oral administration of nobiletin in mice. Anti-inflammatory effects of 4DN were studied in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. The results showed 4DN not only dose-dependently inhibited LPS-induced nitric oxide production, but also significantly reduced expression of pro-inflammatory mediators, namely PGE(2), IL-1 beta and IL-6. 4DN potently suppressed the expression of iNOS and COX-2 at both protein and mRNA levels. 4DN also inhibited nuclear translocation of NF-kappa B and AP-1. Furthermore, we demonstrated that 4DN activated transcription factor Nrf2 and its dependent genes including HO-1 and NQO1 whose expression may contribute to anti-inflammatory effects. The results demonstrated anti-inflammatory effects of 4DN and provided a scientific basis for using nobiletin as a nutraceutical to inhibit inflammation-driven diseases. (C) 2015 Elsevier Ltd. All rights reserved.
分类号: TS2
- 相关文献
作者其他论文 更多>>
-
New vegetable field converted from rice paddy increases net economic benefits at the expense of enhanced carbon and nitrogen footprints
作者:He, Zhilong;Xu, Minggang;Zhang, Wenju;Wu, Lei;He, Zhilong;Zhang, Ying;Hu, Ronggui;Wu, Xian;Tang, Shuirong;Zhang, Ying;He, Zhilong;Wu, Lei
关键词:Newly converted vegetable field; Life cycle assessment; Carbon and nitrogen footprints; Net ecosystem economic benefit
-
Integrative Analysis of Transcriptome and Metabolome Sheds Light on Flavonoid Biosynthesis in the Fruiting Body of Stropharia rugosoannulata
作者:Wu, Xian;Fu, Shaobin;Du, Zhihui;Liu, Lian;Chen, Zhilin;Li, Yurong
关键词:flavonoids; Stropharia rugosoannulata; fruiting body; metabolomics; transcriptomics
-
Pectins amidated with different amino acids via MMTM activation: Structural characteristics and emulsifying properties
作者:Wang, Jirong;Zhao, Chengying;Chen, Yuying;Wang, Fengzhang;Feng, Liping;Wang, Yanqi;Li, Chunhong;Zheng, Jinkai;Bao, Yuming;Zheng, Jinkai
关键词:Pectins; Amino acid; Amidation; MMTM; Emulsifying property
-
Structure characterization and gelling properties of RG-I-enriched pectins extracted from citrus peels using four different methods
作者:Wang, Xueping;Zhao, Chengying;Wang, Jirong;Lu, Xingmiao;Zheng, Jinkai;Wang, Xueping;Zhang, Deli;Bao, Yuming;Zheng, Jinkai
关键词:Citrus; Pectin; RG-I; Chemical structure; Gelling property
-
Strain specificity of lactobacilli with promoted colonization by galactooligosaccharides administration in protecting intestinal barriers during Salmonella infection
作者:Wu, Yujun;Zhang, Xiangyu;Liu, Xiaoyi;Li, Yi;Han, Dandan;Pi, Yu;Wang, Junjun;Whitmore, Melanie A.;Zhang, Guolong;Lu, Xingmiao;Zheng, Jinkai
关键词:Galactooligosaccharides; Lactobacillus; Salmonella; Intestinal inflammation
-
Multi-phenotype response and cadmium detection of rice stem under toxic cadmium exposure
作者:Wang, Wei;Wang, Leiping;Xiao, Hang;Wang, Wei;Man, Zun;Li, Xiaolong;Chen, Rongqin;Pan, Tiantian;Liu, Fei;Wang, Wei;Wang, Leiping;Xiao, Hang;Zhao, Yiying;Dai, Xiaorong
关键词:Rice stem; Cadmium; Plant phenotype; Lipid peroxidation; Laser-induced breakdown spectroscopy; Machine learning
-
Effect of Roasting on the Chemical Composition and Oxidative Stability of Tomato (Solanum lycopersicum L.) Seed Oil
作者:Niu, Zhiya;Zhu, Zhongyan;Zhou, Jing;Xu, Chengjian;Niu, Zhiya;Wei, Changqing;Liu, Wenyu;Wei, Changqing;Liu, Zhanxia;Wang, Ting;Xiao, Hang
关键词:tomato seed oil; roasting; chemical composition; oxidative stability index