Anti-inflammatory effects of 4 '-demethylnobiletin, a major metabolite of nobiletin

文献类型: 外文期刊

第一作者: Wu, Xian

作者: Wu, Xian;Song, Mingyue;Rakariyatham, Kanyasiri;Zheng, Jinkai;Guo, Shanshan;Xiao, Hang;Zheng, Jinkai;Guo, Shanshan;Tang, Zhonghai;Zhou, Shuangde;Xiao, Hang

作者机构:

关键词: 4 '-Demethylnobiletin;Nobiletin;Anti-inflammation;NF-kappa B;Nrf2;Metabolites

期刊名称:JOURNAL OF FUNCTIONAL FOODS ( 影响因子:4.451; 五年影响因子:4.907 )

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收录情况: SCI

摘要: Nobiletin, a citrus flavonoid, has been associated with various beneficial biological activities. 4'-Demethylnobiletin (4DN) is a major metabolite of nobiletin, and its tissue level was found to be much higher than that of nobiletin after oral administration of nobiletin in mice. Anti-inflammatory effects of 4DN were studied in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. The results showed 4DN not only dose-dependently inhibited LPS-induced nitric oxide production, but also significantly reduced expression of pro-inflammatory mediators, namely PGE(2), IL-1 beta and IL-6. 4DN potently suppressed the expression of iNOS and COX-2 at both protein and mRNA levels. 4DN also inhibited nuclear translocation of NF-kappa B and AP-1. Furthermore, we demonstrated that 4DN activated transcription factor Nrf2 and its dependent genes including HO-1 and NQO1 whose expression may contribute to anti-inflammatory effects. The results demonstrated anti-inflammatory effects of 4DN and provided a scientific basis for using nobiletin as a nutraceutical to inhibit inflammation-driven diseases. (C) 2015 Elsevier Ltd. All rights reserved.

分类号: TS2

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