Effects of nitrite exposure on haematological parameters, oxidative stress and apoptosis in juvenile turbot (Scophthalmus maximus)

文献类型: 外文期刊

第一作者: Jia, Rui

作者: Jia, Rui;Huo, Huan-Huan;Jia, Rui;Lei, Ji-Lin;Liu, Bao-Liang;Huang, Bin;Yin, Shu-Ting;Han, Cen

作者机构:

关键词: Nitrite;Oxidative stress;Apoptosis;Gills;Scophthalmus maximus

期刊名称:AQUATIC TOXICOLOGY ( 影响因子:4.964; 五年影响因子:5.071 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Nitrite (NO2-) is commonly present as contaminant in aquatic environment and toxic to aquatic organisms. In the present study, we investigated the effects of nitrite exposure on haematological parameters, oxidative stress and apoptosis in juvenile turbot (Scophthalmus maximus). Fish were exposed to various concentrations of nitrite (0, 0.02, 0.08, 0.4 and 0.8 mM) for 96 h. Fish blood and gills were collected to assay haematological parameters, oxidative stress and expression of genes after 0, 24, 48 and 96 h of exposure. In blood, the data showed that the levels of methemoglobin (MetHb), triglyceride (TG), potassium (K+), cortisol, heat shock protein 70 (HSP70) and glucose significantly increased in treatments with higher concentrations of nitrite (0.4 and/or 0.8 mM) after 48 and 96 h, while the levels of haemoglobin (Hb) and sodium (Na+) significantly decreased in these treatments. In gills, nitrite (0.4 and/or 0.8 mM) apparently reduced the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH), increased the formation of malondialdehyde (MDA), up-regulated the mRNA levels of c-jun amino-terminal kinase (JUK1), p53, caspase-3, caspase-7 and caspase-9 after 48 and 96 h of exposure. The results suggested caspase-dependent and JUK signaling pathways played important roles in nitrite-induced apoptosis in fish. Further, this study provides new insights into how nitrite affects the physiological responses and apoptosis in a marine fish. (C) 2015 Elsevier B.V. All rights reserved.

分类号: Q17

  • 相关文献

[1]The physiological performance and immune response of juvenile turbot (Scophthalmus maximus) to nitrite exposure. Jia, Rui,Lei, Ji-Lin,Han, Cen.

[2]Identification and mRNA expression of antioxidant enzyme genes associated with the oxidative stress response in the Wuchang bream (Megalobrama amblycephala Yih) in response to acute nitrite exposure. Sun, Shengming,Ge, Xianping,Zhu, Jian,Xuan, Fujun,Jiang, Xiaojun. 2014

[3]Effects of ammonia exposure on stress and immune response in juvenile turbot (Scophthalmus maximus). Jia, Rui,Lei, Ji-Lin,Liu, Bao-Liang,Huang, Bin,Han, Cen.

[4]Oxidative Stress-Mediated Cytotoxicity of Cadmium in Chicken Splenic Lymphocytes. Li, Jin-Long,Tang, Zhao-Xin,Li, Jin-Long,Li, Shu,Xu, Shi-Wen,Li, Hui-Xin,Wang, Xiao-Long. 2010

[5]Facile fabrication of graphene oxide loaded with silver nanoparticles as antifungal materials. Cui, Jianghu,Yang, Yunhua,Zheng, Mingtao,Liu, Yingliang,Xiao, Yong,Lei, Bingfu,Chen, Wei. 2014

[6]Protective Effects of Quercetin on Cadmium-induced Cytotoxicity in Primary Cultures of Rat Proximal Tubular Cells. Wang Lin,Liu Gang,Wang Zhen Yong,Lin Shu Qian,He Yuan Long. 2013

[7]Toxic dinoflagellate Alexandrium tamarense induces oxidative stress and apoptosis in hepatopancreas of shrimp (Fenneropenaeus chinensis). Liang Zhongxiu,Ren Hai,Liang Zhongxiu,Li Jian,Li Jitao,Tan Zhijun,Zhao Fazhen. 2014

[8]Rhizoma smilacis glabrae protects rats with gentamicin-induced kidney injury from oxidative stress-induced apoptosis by inhibiting caspase-3 activation. Liu, Cuiyan,Kang, Youxi,Yang, Zisheng,Han, Chunyang,Zhou, Xiuhong,Gu, Jingang.

[9]Molecular cloning, immunohistochemical localization, characterization and expression analysis of caspase-8 from the blunt snout bream (Megalobrama amblycephala) exposed to ammonia. Sun, Shengming,Ge, Xianping,Zhu, Jian,Zhang, Wuxiao,Zhang, Qiong.

[10]Immune and physiological responses of pufferfish (Takifugu obscurus) under cold stress. Cheng, Chang-Hong,Guo, Zhi-Xun,Ye, Chao-Xia,Wang, An-Li,Guo, Zhi-Xun.

[11]Cytoprotective effect of deferiprone against aluminum chloride-induced oxidative stress and apoptosis in lymphocytes. Zhuang, Cuicui,Zhang, Haiyang,Song, Miao,Han, Yanfei,Li, Yanfei,She, Yue,Zhu, Yanzhu. 2018

[12]Long-term High-fat High-sucrose Diet Promotes Enlarged Islets and beta-Cell Damage by Oxidative Stress in Bama Minipigs. Zhao, Zhan-zhao,Xin, Lei-lei,Xia, Ji-han,Yang, Shu-lin,Li, Kui,Zhao, Zhan-zhao,Chen, Yao-xing. 2015

[13]Protective Effects of Cynaroside Against H2O2-Induced Apoptosis in H9c2 Cardiomyoblasts. Sun, Xiao-bo,Sun, Xiao-bo. 2011

[14]Carbendazim has the potential to induce oxidative stress, apoptosis, immunotoxicity and endocrine disruption during zebrafish larvae development. Jiang, Jinhua. 2015

[15]Pretilachlor has the potential to induce endocrine disruption, oxidative stress, apoptosis and immunotoxicity during zebrafish embryo development. Jiang, Jinhua,Chen, Yanhong,Yu, Ruixian,Zhao, Xueping,Wang, Qiang,Cai, Leiming. 2016

[16]An isoflavonoid-enriched extract from Pueraria lobata (kudzu) root protects human umbilical vein endothelial cells against oxidative stress induced apoptosis. Gao, Ying,Gao, Ying,Wang, Xu,He, Chunnian.

[17]X/XO or H2O2 induced IPEC-J2 cell as a new in vitro model for studying apoptosis in post-weaning piglets. Cai, Xuan,Zhu, Lihui,Sheng, Yongshuai,Guo, Qi,Bao, Jian,Xu, Jianxiong,Cai, Xuan,Zhu, Lihui,Sheng, Yongshuai,Guo, Qi,Bao, Jian,Xu, Jianxiong,Chen, Xiaolian.

[18]Neuroprotection against hydrogen peroxide-induced toxicity by Dictyophora echinovolvata polysaccharide via inhibiting the mitochondria-dependent apoptotic pathway. Yu, Wen-Xuan,Dong, Xiao-Li,Lin, Chen-Qiang,Lin, Xin-Jian,Yu, Wen-Xuan,Dong, Xiao-Li,Yu, Wen-Xuan,Dong, Xiao-Li,Zhao, Qing.

[19]Effects of water-borne copper on the gills and hepatopancreas of Macrobrachium rosenbergii. Li, Na,Ma, Qiang,Zhao, Yunlong,Yang, Jian,Li, Na,Brochon, Jean-Claude. 2008

[20]Molecular cloning, characterization and expression analysis of gonadal P450 aromatase in the half-smooth tongue-sole, Cynoglossus semilaevis. Deng, Si-Ping,Chen, Song-Lin,Xu, Jian-Yong,Liu, Ben-Wei,Deng, Si-Ping.

作者其他论文 更多>>