CHARACTERIZATION OF THREE OLEANE-TYPE SAPONINS FROM Panax ginseng

文献类型： 外文期刊

第一作者： Jin, Yin-Ping

作者： Jin, Yin-Ping;Yan, Shi;Wang, Ying-Ping;Li, Wei

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期刊名称：CHEMISTRY OF NATURAL COMPOUNDS （ 影响因子：0.809； 五年影响因子：0.708 ）

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收录情况： SCI

摘要： Ginseng, the root and rhizome of Panax ginseng C. A. Mey. (Araliaceae), has been used as a very old Chinese medicine by the people in the Eastern Asia regions for over 2000 years. P. ginseng has very extensive pharmacological activities, including anti-fatigue and antidiabetes, as well as activities in the prevention of cancer and slowing the aging process [1—3]. The pharmacological properties of ginseng are generally attributed to ginsenosides. Based on the structure of aglycone, the ginsenosides can be divided into protopanaxadiol-type saponins (PPD), protopanaxatriol-type saponins (PPT), and oleanane-type saponins. More than 150 ginsenosides have been isolated from various parts of ginseng and processed ginseng so far [4-11], which belong mainly to dammarane-type saponins. However, to date, only four oleanane-type saponins have been isolated from P. ginseng, including ginsenoside-Ro , ginsenoside-Ro methyl, polyacetylene ginsenoside-Ro [12], and ginsenoside-Ri [13]. In this study, three oleanane-type saponins, identified as chikusetsusaponin IVa (1), zingibroside R, (2), and oleanolic acid 28-O-β-D-glucopyranoside (3), were further isolated from the plant. Numerous activity studies have been performed on the dammarane-type ginsenosides, but little attention has been focused on oleanane-type ginsenosides. To further investigate their antitumor activities, cytotoxicity assays against HepG2, В16, and Lewis tumor cell lines in vitro have been performed using MTT methods.

分类号： O6

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