Physiological Responses in Chinese Rare Minnow Larvae Following Exposure to Low-Dose Tributyltin

文献类型: 外文期刊

第一作者: Li, Ping

作者: Li, Ping;Li, Zhi-Hua;Li, Ping;Li, Zhi-Hua

作者机构:

关键词: Tributyltin;Chinese rare minnow;Physiological responses;Gene expression

期刊名称:BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY ( 影响因子:2.151; 五年影响因子:2.129 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: In the present study, the antioxidant response and acetylcholinesterase (AChE) activity were measured in Chinese rare minnow larvae (Gobiocypris rarus) after exposure to tributyltin (TBT) (0, 100, 400 and 800 ngL(-1)) for 7 days, as well as the expression of a series of genes, including cr, aptase and prl genes involved in the ion-regulatory process and igfbp3 and gh related to growth rate. Results shows that oxidative stress was generated in fish exposed to TBT, as evidenced by elevated malondialdehyde levels and the inhibition of antioxidant parameters. The activity of acetylcholinesterase (AChE) was also inhibited in fish under higher TBT stress. Moreover, genes involved in ion regulation and growth were affected, based on the regulated transcription of the cr, atpase, gh, prl and igfbp3 genes in the treated groups. The observed effects of TBT upon antioxidant responses and altered expression of genes provides insight into the use of these molecular biomarkers in evaluating mechanisms of TBT toxicity in fish.

分类号: R99

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