Enhancement of Palmarumycin C-12 and C-13 Production by the Endophytic Fungus Berkleasmium sp Dzf12 in an Aqueous-Organic Solvent System

文献类型： 外文期刊

第一作者： Mou, Yan

作者： Mou, Yan;Xu, Dan;Mao, Ziling;Dong, Xuejiao;Lin, Fengke;Wang, Ali;Lai, Daowan;Zhou, Ligang;Xie, Bingyan

作者机构：

关键词： endophytic fungus;Berkleasmium sp;Dzf12;Dioscorea zingiberensis;palmarumycin C-12;palmarumycin C-13;production;aqueous-organic solvent system;butyl oleate;liquid paraffin

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The endophytic fungus Berkleasmium sp. Dzf12, isolated from Dioscorea zingiberensis, was found to produce palmarumycins C-12 and C-13 which possess a great variety of biological activities. Seven biocompatible water-immiscible organic solvents including n-dodecane, n-hexadecane, 1-hexadecene, liquid paraffin, dibutyl phthalate, butyl oleate and oleic acid were evaluated to improve palmarumycins C-12 and C-13 production in suspension culture of Berkleasmium sp. Dzf12. Among the chosen solvents both butyl oleate and liquid paraffin were the most effective to improve palmarumycins C-12 and C-13 production. The addition of dibutyl phthalate, butyl oleate and oleic acid to the cultures of Berkleasmium sp. Dzf12 significantly enhanced palmarumycin C-12 production by adsorbing palmarumycin C-12 into the organic phase. When butyl oleate was fed at 5% (v/v) in medium at the beginning of fermentation (day 0), the highest palmarumycin C-12 yield (191.6 mg/L) was achieved, about a 34.87-fold increase in comparison with the control (5.3 mg/L). n-Dodecane, 1-hexadecene and liquid paraffin had a great influence on the production of palmarumycin C-13. When liquid paraffin was added at 10% (v/v) in medium on day 3 of fermentation, the palmarumycin C-13 yield reached a maximum value (134.1 mg/L), which was 4.35-fold that of the control (30.8 mg/L). Application of the aqueous-organic solvent system should be a simple and efficient process strategy for enhancing palmarumycin C-12 and C-13 production in liquid cultures of the endophytic fungus Berkleasmium sp. Dzf12.

分类号： O62

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