Anti-HIV terpenoids from Daphne aurantiaca Diels. stems

文献类型: 外文期刊

第一作者: Huang, Sheng-Zhuo

作者: Huang, Sheng-Zhuo;Ma, Qing-Yun;Dai, Hao-Fu;Wang, Qi;Zhao, You-Xing;Zhang, Xuan;Zheng, Yong-Tang;Zhou, Jun

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期刊名称:RSC ADVANCES ( 影响因子:3.361; 五年影响因子:3.39 )

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收录情况: SCI

摘要: Thirteen new sesquiterpenoids, including six guaiane type auranticanols A-F (1, 2, and 4-7) and seven carotene type auranticanols G-M (18-24) were isolated from the stems of Daphne aurantiaca Diels., along with fourteen known sesquiterpenoids (3, 8-17, 25-27) and two known tigliane diterpenoids (28, 29), and their structures were elucidated by extensively analyzing their MS and NMR spectroscopic data. A bioassay of anti-HIV activity indicated that compounds 11, 14, 19, and 28 showed definite activities with EC50 values of 2.138, 0.286, 1.773 and 0.000282 mu g mL(-1) and SI > 93.545, 93.787, 10.243, and 65 177.305, respectively.

分类号: O6

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