Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30

文献类型： 外文期刊

第一作者： Zhou, Xuefeng

作者： Zhou, Xuefeng;Lin, Xiuping;Yang, Bingjie;Liu, Yonghong;Fang, Wei;Tan, Suiyi;Xun, Tianrong;Yang, Bingjie;Liu, Shuwen

作者机构：

关键词： Aspergillus niger;Aspernigrins;Malformin C;HIV-1 SF162

期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.823； 五年影响因子：2.677 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Two new 2-benzylpyridin-4-one containing metabolites, aspernigrins C (3) and D (4), together with six known compounds (1, 2, and 5-8), were isolated from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. The structures of the new compounds were determined by NMR, MS, and optical rotation analyses. All the isolated compounds were evaluated for their inhibitory activities against infection with HIV-1 SF162 in TZM-bl cells. Malformin C (5) showed the strongest anti-HIV-1 activity with IC50 of 1.4 +/- 0.06 mu M (selectivity index, 11.4), meanwhile aspernigrin C (3) also exhibited potent activity with IC50 of 4.7 +/- 0.4 mu M (selectivity index, 7.5). (C) 2015 Elsevier Ltd. All rights reserved.

分类号： R9

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