Baicalin Inhibits the Lethality of Shiga-Like Toxin 2 in Mice

文献类型： 外文期刊

第一作者： Dong, Jing

作者： Dong, Jing;Zhang, Yong;Zhang, Yu;Deng, Xuming;Dong, Jing;Chen, Yutao;Wang, Quan;Li, Xuemei;Niu, Xiaodi;Yang, Cheng

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期刊名称：ANTIMICROBIAL AGENTS AND CHEMOTHERAPY （ 影响因子：5.191； 五年影响因子：5.346 ）

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收录情况： SCI

摘要： Shiga-like toxins (Stxs), produced by pathogenic Escherichia coli, are a major virulence factor involved in severe diseases in human and animals. These toxins are ribosome-inactivating proteins, and treatment for diseases caused by them is not available. Therefore, there is an urgent need for agents capable of effectively targeting this lethal toxin. In this study, we identified baicalin, a flavonoid compound used in Chinese traditional medicine, as a compound against Shiga-like toxin 2 (Stx2). We found that baicalin significantly improves renal function and reduces Stx2-induced lethality in mice. Further experiments revealed that baicalin induces the formation of oligomers by the toxin by direct binding. We also identified the residues important for such interactions and analyzed their roles in binding baicalin by biophysical and biochemical analyses. Our results establish baicalin as a candidate compound for the development of therapeutics against diseases caused by Stxs.

分类号： R45

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