The function of feline stimulator of interferon gene (STING) is evolutionarily conserved

文献类型： 外文期刊

第一作者： Zhang, Xiaozhan

作者： Zhang, Xiaozhan;Wu, Hongxia;Liu, Chunguo;Sun, Xue;Zu, Shaopo;Tian, Jin;Qu, Liandong;Li, Shoujun;Sun, Xue;Zu, Shaopo;Li, Shoujun

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关键词： Feline;STING;Type I IFN;Activation

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：2.046； 五年影响因子：2.217 ）

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收录情况： SCI

摘要： Stimulator of interferon gene (STING) mediates the induction of type I IFN responses. In this study, feline STING was cloned. Full-length STING contains 1134 by and encodes a 377 amino acid product that shares the highest similarity with bovine STING. STING is primarily expressed in the spleen, lungs and lymph nodes. An examination of its cellular localization indicated that STING is localized in the endoplasmic reticulum (ER) and contains two ER retention motifs, RPR and KKNF. Overexpressing STING induced the IFN response via the IRF3, NF-kappa B and AP-1 pathways. Moreover, the C-terminus of STING was required for the activation of IRF3 and AP-1. Knockdown of STING impaired the IFN-beta response triggered by poly(dA:dT), poly(I:C) or SeV. Finally, STING activated the ISRE promoter and increased the expression of ISG15 and viperin. Collectively, our findings indicate that STING is involved in the regulation of the IFN-beta pathway in felines. (C) 2015 Elsevier B.V. All rights reserved.

分类号： S85

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