Protective action of the phyllanthin against carbon tetrachloride-induced hepatocyte damage in Cyprinus carpio

文献类型： 外文期刊

第一作者： Jia, Rui

作者： Jia, Rui;Liu, Ying-Juan;Xu, Pao;Yin, Guo-Jun;Jia, Rui;Du, Jin-Liang;Cao, Li-Ping;Xu, Pao;Yin, Guo-Jun;Du, Jin-Liang;Cao, Li-Ping;Xu, Pao;Yin, Guo-Jun

作者机构：

关键词： Phyllanthin;Carbon tetrachloride;Hepatoprotective action;Cytochrome P450;Cyprinus carpio

期刊名称：IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL （ 影响因子：2.416； 五年影响因子：2.117 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The present study was to investigate the protective effect and possible mechanism of phyllanthin against carbon tetrachloride (CCl4)-induced hepatocyte damage in carp. Phyllanthin (5, 10, and 15 mu g/ml) was added to carp primary hepatocytes before (pre-treatment) and after (post-treatment) incubation of the hepatocytes in medium containing CCl4 at 8 mM; supernatant and cell were collected for the analyses of cell viability, biochemical parameters, and gene expression. The results showed that phyllanthin at the concentration of 15 mu g/ml significantly suppressed the elevation of glutamate pyruvate transaminase (GPT), glutamate oxalate transaminase (GOT), lactate dehydrogenase (LDH), and malondialdehyde (MDA), and the reduction of cell viability, superoxide dismutase (SOD) activity, cytochrome P450 1a (CYP1A), and cytochrome P450 3a (CYP3A) messenger RNA (mRNA) levels expect LDH in the post-treatment. The levels of GPT, GOT, and CYP1A mRNA were also effectively restored in the pre-treatment with phyllanthin (10 mu g/ml). Overall, our results suggested that phyllanthin may be used as a hepatoprotective agent to prevent liver diseases in fish.

分类号： Q95

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