A novel strain of Lactobacillus mucosae isolated from a Gaotian villager improves in vitro and in vivo antioxidant as well as biological properties in D-galactose-induced aging mice

文献类型： 外文期刊

第一作者： Yu, Xiaomin

作者： Yu, Xiaomin;Li, Shengjie;Yang, Dong;Qiu, Liang;Wu, Yaoping;Wang, Dengyuan;Xu, Feng;Wei, Hua;Yu, Xiaomin;Li, Shengjie;Yang, Dong;Qiu, Liang;Wu, Yaoping;Wang, Dengyuan;Wei, Hua;Li, Shengjie;Shah, Nagendra P.

作者机构：

关键词： antioxidant activity;2;2-diphenyl-1-picrylhydrazyl;hydroxyl radical;reducing power;D-galactose-induced aging mice

期刊名称：JOURNAL OF DAIRY SCIENCE （ 影响因子：4.034； 五年影响因子：4.354 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Twelve isolates isolated from the gastrointestinal tracts of Gaotian villagers in China, who had a lifespan of 92 yr, were examined for their antioxidants using free radical scavenging activity and 2,2-diphenyl-1-picrylhydrazyl. Three strains (i.e., Lactobacillus mucosae LMU1001, and Lactobacillus plantarum LPL0902 and LPL0302) were selected as candidates to prepare yogurt for testing their antioxidants in a model of D-galactose-induced aging mice, with vitamin C as a positive control. The results showed that L. mucosae LMU1001 was the best strain, which had similar in vivo antioxidant activity as vitamin C. A significant increase was found in the activities of glutathione peroxidase in serum and total superoxide dismutase in the liver, and a decrease in the level of malondialdehyde in serum. Regarding mRNA expression level detected quantitatively by real-time PCR, we observed that L. mucosae LMU1001 significantly upregulated antioxidant genes (i.e., MT1A and MT1M in HT-29 and Caco-2) and those genes (i.e., MT1, MT2, GPx1, and GPx2) in the intestinal tract of the model mice. Hence, this strain could be considered as a potential probiotic lactic acid bacterium for improving antioxidant levels in functional foods.

分类号： TS252

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