Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin

文献类型: 外文期刊

第一作者: Li, Zhi-Hua

作者: Li, Zhi-Hua;Li, Ping;Shi, Ze-Chao;Li, Zhi-Hua;Li, Ping

作者机构:

关键词: tributyltin;fish brain;physiological parameters;molecular responses

期刊名称:ENVIRONMENTAL TOXICOLOGY ( 影响因子:4.119; 五年影响因子:3.404 )

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年卷期:

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收录情况: SCI

摘要: Tributyltin (TBT), as antifouling paints, is widely present in aquatic environment, but little is known regarding the toxicity of TBT on fish brain. In this study, the effects of exposure to TBT on the antioxidant defense system, Na+-K+-ATPase activity, neurological enzymes activity and Hsp 70 protein level in brain of juvenile common carp (Cyprinus carpio) were studied. Fish were exposed to sublethal concentrations of TBT (5, 10 and 20 g/L) for 7 days. Based on the results, with increasing concentrations of TBT, oxidative stress was apparent as reflected by the significant higher levels of oxidative indices, as well as the significant inhibition of all antioxidant enzymes activities. Besides, the activities of Acetylcholinesterase (AChE), Monoamine oxidases (MAO) and Na+-K+-ATPase were significantly inhibited after exposure to TBT with higher concentrations. In addition, the levels of Hsp 70 protein were evaluated under TBT stress with dose-depended manner. These results suggest that selected physiological responses in fish brain could be used as potential biomarkers for monitoring residual organotin compounds present in aquatic environment. (c) 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 278-284, 2016.

分类号: R9

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