Molecular cloning, tissue and embryonic development expression, and appetite regulatory effect of pancreatic peptide Y in Coilia nasus
文献类型: 外文期刊
第一作者: Yang, Siyu
作者: Yang, Siyu;Xu, Gangchun;Xu, Pao;Xu, Gangchun;Du, Fukuan;Xu, Pao
作者机构:
关键词: Coilia nasus;PY;Molecular cloning;Appetite;Fasting
期刊名称:FISHERIES SCIENCE ( 影响因子:1.617; 五年影响因子:1.531 )
ISSN:
年卷期:
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收录情况: SCI
摘要: Pancreatic peptide Y (PY) is a member of the neuropeptide Y family and is the result of duplication of the peptide YY gene, an anorexigenic neuropeptide that has been identified in mammals and some teleost species. The physiological function of PY in the regulation of appetite is not clear. In this study, highly conserved PY cDNA was characterized in Coilia nasus. The tissue distribution of C. nasus PY mRNA was analyzed by real-time PCR, demonstrating high levels of expression in the brain, intestine, and liver, but also with widespread distribution in other tissues. During embryogenesis, C. nasus PY mRNA was detected in early-stage developing embryos and was observed to increase throughout larval development. Expression of C. nasus PY mRNA initially decreased and then increased during fasting, suggesting a potential relationship between food intake and the expression of PY. This study has revealed a potential role for PY in appetite regulation and provides a basis for further study of PY in C. nasus.
分类号: S9
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