Structure elucidation of a bioactive polysaccharide from fruiting bodies of Hericium erinaceus in different maturation stages

文献类型： 外文期刊

第一作者： Li, Qiao-Zhen

作者： Li, Qiao-Zhen;Wu, Di;Zhou, Shuai;Liu, Yan-Fang;Li, Zheng-peng;Feng, Jie;Yang, Yan;Li, Qiao-Zhen;Wu, Di;Zhou, Shuai;Liu, Yan-Fang;Li, Zheng-peng;Feng, Jie;Yang, Yan

作者机构：

关键词： Hericium erinaceus;Maturation stage;Polysaccharide;Macrophage activation;Structural analysis

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： HPB-3, a heteropolysaccharide, with a mean molecular weight of 1.5 x 10(4) Da, was obtained from the maturating-stage IV, V and VI fruiting body of Hericium erinaceus, exhibited higher macrophages stimulation activities, was able to upregulate the functional events mediated by activated macrophages, such as production of nitric oxide ( NO). Monosaccharide composition analysis showed that HPB-3 comprised L-fucose, D-galactose and D-glucose in the ratio of 5.2: 23.9: 1. Its chemical structure was characterized by sugar and methylation analysis, along with H-1 and C-13 NMR spectroscopy, including H-1-H-1 COSY, TOCSY, NOESY, HMQC and HMBC experiments. The results indicated that HPB-3 contained a-(1/6)-linked galactopyranosyl backbone, partially with a side chain composed of alpha-L-fucopyranose at the O-2 position. The predicted primary structure of the polysaccharide was established as below:

分类号： O629`Q53

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