New Phragmalin-Type Limonoids from Chukrasia tabularis and Their alpha-Glucosidase Inhibitory Activity

文献类型： 外文期刊

第一作者： Peng, Jun-Lin

作者： Peng, Jun-Lin;Wang, Jun;Kong, Fan-Dong;Wang, Pei;Gai, Cui-Juan;Mei, Wen-Li;Dai, Hao-Fu;Peng, Jun-Lin;Liu, Zi-Qi;Jiang, Bei

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关键词： Chukrasia tabularis;Meliaceae;limonoid;-Glucosidase inhibition activity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

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收录情况： SCI

摘要： Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1-5, named chukbularisins A-E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro -glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against -glucosidase with IC50 values of 0.06 +/- 0.008, 0.04 +/- 0.002, 0.52 +/- 0.039, 1.09 +/- 0.040, and 0.20 +/- 0.057 mM, respectively (using acarbose as positive control, IC50 0.95 +/- 0.092 mM).

分类号： O62

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