Syndecan-4, a PRRSV attachment factor, mediates PRRSV entry through its interaction with EGFR

文献类型： 外文期刊

第一作者： Wang, Rui

作者： Wang, Rui;Wang, Xin;Ni, Bo;Huan, Chang-chao;Fan, Hong-jie;Mao, Xiang;Liao, Ying;Tong, Guang-zhi;Ding, Chan;Mao, Xiang;Wu, Jia-qiang;Wen, Li-bin

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关键词： Porcine reproductive and respiratory;syndrome virus;Attachment;Entry;Syndecan-4;EGFR

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

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收录情况： SCI

摘要： The causative agent of porcine reproductive and respiratory syndrome is the PRRS virus (PRRSV), an enveloped, single-stranded and positive-sense RNA virus. The host factors and mechanisms that are involved in PRRSV entry are still largely unknown. In our present studies, we found that syndecan-4, one of the heparan sulfate proteoglycans, plays a critical role in PRRSV entry, especially in PRRSV attachment. Moreover, EGFR interacts with syndecan-4 in MACR-145 cells and disruption of their interaction impaired PRRSV entry. Furthermore, EGFR inhibitor AG1478 or syndecan-4 derived peptide SSTN87-131 inhibited syndecan-4 endocytosis induced by PRRSV entry. Altogether, syndecan-4, a PRRSV attachment factor, mediated PRRSV entry by interacting with EGFR. (C) 2016 Elsevier Inc. All rights reserved.

分类号： Q5

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