Flaxseed lignans alleviate high fat diet-induced hepatic steatosis and insulin resistance in mice: Potential involvement of AMP-activated protein kinase

文献类型： 外文期刊

第一作者： Sun, Jian

作者： Sun, Jian;Tang, Yuhan;Yu, Xiao;Xu, Yanyan;Liu, Peiyi;Xiao, Lin;Liu, Liegang;Yao, Ping;Sun, Jian;Tang, Yuhan;Yu, Xiao;Xu, Yanyan;Liu, Peiyi;Xiao, Lin;Liu, Liegang;Yao, Ping;Deng, Qianchun;Deng, Qianchun

作者机构：

关键词： Flaxseed;Secoisolariciresinol diglucoside;Hepatic steatosis;Insulin resistance;Insulin signalling;AMP-activated protein kinase

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Hepatic steatosis and insulin resistance are highly prevalent and play a vital role in the development of nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). The present study examined the protective effects of naturally occurring flaxseed lignan secoisolariciresinol diglucoside (SDG) on these metabolic disorders resulting from high fat diet (HFD). SDG (0.05%, w/w) supplementation for 16 weeks attenuated body weight gain, hyperlipidaemia and hepatic steatosis in HFD (60% kcal from fat)-challenged C57BL/6J mice. Moreover, SDG lowered fasting serum glucose and insulin, and improved homeostasis model assessment of insulin resistance (HOMA-IR) index, glucose tolerance, and insulin response in HFD-fed mice. Furthermore, SDG prevented HFD-induced inhibition of protein kinase B, insulin receptor substrate-1 and AMP-activated protein kinase activation in the liver of HFD-fed mice. These findings indicate that SDG supplementation alleviates hepatic steatosis and insulin resistance, at least in part, by enhancing insulin signalling and AMPK activation. (c) 2016 Elsevier Ltd. All rights reserved.

分类号： TS2

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