Stereoselective induction by 2,2 ',3,4 ',6-pentachlorobiphenyl in adult zebrafish (Danio rerio): Implication of chirality in oxidative stress and bioaccumulation
文献类型: 外文期刊
第一作者: Chai, Tingting
作者: Chai, Tingting;Cui, Feng;Mu, Xiyan;Yang, Yang;Qi, Suzhen;Zhu, Lizhen;Wang, Chengju;Chai, Tingting;Qiu, Jing
作者机构:
关键词: PCB91;Zebrafish;Oxidative stress;Bioconcentration
期刊名称:ENVIRONMENTAL POLLUTION ( 影响因子:8.071; 五年影响因子:8.35 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: This study aimed to investigate the oxidative stress process and bioaccumulation the racemic/(-)-/(+)-2,2',3,4',6-pentachlorobiphenyl were administered to adult zebrafish (Danio redo) after prolonged exposure of 56-days uptake and 49-days depuration experiments. Stereoselective accumulation was observed in adult samples after racemic exposure as revealed by decreased enantiomer fractions. The two enantiomers of PCB91 accumulated at different rates with logBCF(k) values close to 3.7, suggesting that they were highly hazardous and persistent pollutants. Exposure to racemic/(-)-/(+)- PCB91 stereo selectively induced oxidative stress owing to changes in reactive oxygen species, malondialdehyde contents, antioxidant enzyme activities and gene expressions in brain and liver tissues. In addition, the stereoselective relationship between bioconcentration and oxidative stress were also presented in this study. Our findings might be helpful for elucidating the environmental risk of the two enantiomers of PCB91 that induce toxicity in aquatic organisms. (C) 2016 Elsevier Ltd. All rights reserved.
分类号: X5
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