Molecular cloning and functional characterization of feline MAVS

文献类型： 外文期刊

第一作者： Wu, Hongxia

作者： Wu, Hongxia;Zhang, Xiaozhan;Liu, Chunguo;Liu, Dafei;Liu, Jiasen;Wang, Guoqing;Tian, Jin;Qu, Liandong

作者机构：

关键词： Feline MAVS;IFN-beta response;miniMAVS;Inhibition

期刊名称：IMMUNOLOGIC RESEARCH （ 影响因子：2.829； 五年影响因子：3.006 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The mitochondrial anti-viral signaling protein (MAVS) plays an important role in the type I IFN response. In this study, two feline MAVS transcripts were cloned. Both transcripts have the same open reading frame encoding 523 amino acids. The putative protein shares 76.6 % similarity with canine and exhibits similarity to human, mouse, rat, bovine and porcine, ranging from 46.1 to 65.8 %. Deletion mutant analysis indicated that the transmembrane (TM) domain is necessary for localization in the mitochondrial membrane, and both the caspase activation and recruitment domain and TM domain are indispensible for activating the IFN-beta response. Additionally, Sendai virus-induced IFN-beta promoter activation was significantly inhibited by siRNA targeting MAVS. Finally, miniMAVS, a second protein encoded by MAVS mRNA, was identified, which interfered with the IFN-beta response via the inhibition of NF-kappa B activation. The identification of MAVS will promote the understanding and control of feline infectious diseases.

分类号： R392

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