Synthesis and biological evaluation of acylated oligorhamnoside derivatives structurally related to mezzettiaside-6 with cytotoxic activity
文献类型： 外文期刊
第一作者： Song, Gaopeng
作者： Song, Gaopeng;Li, Yibin;Li, Junhua;Liao, Yixian;Song, Gaopeng;Cui, Zi-Ning;Li, Sumei;Lei, Zhiwei
作者机构：
期刊名称：ORGANIC & BIOMOLECULAR CHEMISTRY （ 影响因子：3.876； 五年影响因子：3.397 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Two partially acylated oligorhamnoside derivatives 1 and 2 structurally related to the natural product mezzettiaside-6 were synthesized via a '2 + 1 + 1' convergent strategy. The bioassay results showed that the introduction of the acetyl groups to the 2-position of the terminal L-rhamnose was helpful to improve in vitro cytotoxicity. Compound 1 showed both extensive in vitro cytotoxicity in tumor cell lines and potential antimultidrug resistance capability. Preliminary mechanistic studies demonstrated that compound 1 could inhibit cell growth by inducing apoptosis, arresting cell cycle progression at the S phase in K562 cells.
分类号： O64
- 相关文献
作者其他论文 更多>>
-
Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis
作者：Ou, Zhihua;Ren, Peidi;He, Fan;Chen, Jialing;Tan, Qiming;Chen, Qi;Zhang, Qian;Ou, Zhihua;Ren, Peidi;He, Fan;Chen, Jialing;Cai, Huimin;Li, Jiandong;Tan, Qiming;Chen, Qi;He, Xiuju;Zhao, Yanping;Zhang, Qian;Liang, Yingan;Li, Junhua;Li, Li;Zhou, Ting-Ting;Wu, Yao-Dong;Li, Xiu-Rong;Li, Wenhui;Zhang, Nian-Zhang;Chen, Wei-Gang;Sun, Jiwen;Wu, Yan-Tao;You, Jie;Tian, Xue-Qi;Fu, Bao-Quan;Cai, Xue-Peng;Jia, Wan-Zhong;Yan, Hong-Bin;Li, Li;Zhou, Ting-Ting;Wu, Yao-Dong;Li, Xiu-Rong;Li, Wenhui;Zhang, Nian-Zhang;Chen, Wei-Gang;Sun, Jiwen;Wu, Yan-Tao;You, Jie;Tian, Xue-Qi;Fu, Bao-Quan;Cai, Xue-Peng;Jia, Wan-Zhong;Yan, Hong-Bin;He, Fan;Chen, Jialing;Chen, Qi;Zhang, Qian;Cai, Huimin;Li, Jiandong;He, Xiuju;Zhao, Yanping;Liao, Sha;Yang, Huanming;Wang, Jian;Jin, Xin;Xu, Xun;Han, Xiumin;Tan, Qiming;Liang, Yingan;Hu, Guohai;Wang, Jian;Chen, Ao;Chen, Ao;Jin, Xin;Jin, Xin;Xu, Xun;Li, Junhua
关键词：
Echinococcus multilocularis ; macrophages; neutrophils; single-cell RNA sequencing; spatial transcriptomics -
Improvement in soil organic carbon turnover and microbial community niche differentiation with the addition of commercial organic fertilizers in wheat-green manure systems
作者：Cheng, Liyang;He, Hao;Li, Junhua;Min, Tao;Luo, Tong
关键词：Organic substitution; Acid hydrolyzable organic carbon; Solid-state nuclear magnetic resonance; Enzyme activity; Symbiotic network
-
Acidic compost tea reduces fungal diversity but improves community structure and P availability in calcareous cotton fields
作者：Cheng, Liyang;Luo, Tong;Min, Tao;Li, Junhua;Luo, Tong;Min, Tao
关键词：Compost tea; Rhizosphere; Phosphorus; Fungi guilds; Microbial community
-
Variations of physical properties, bioactive phytochemicals, antioxidant capacities and PPO activities of cantaloupe melon (Cucumis melo L.) slices subjected to different drying methods
作者：Gao, Xin;Yang, Junyan;Wang, Haojie;Mao, Jiancai;Wu, Lipeng;Li, Junhua;Wang, Xuhui;Gao, Xin
关键词：cantaloupe melon; drying methods; bioactive compounds; antioxidant activities; PPO activity
-
Positive effects of nitrogen fertilization on the flavor ingredients of tea (Wuniuzao), soil physicochemical properties, and microbial communities
作者：Yin, Rongxiu;Li, Lulu;Liu, Huifang;Yao, Jianmei;Ma, Chiyu;Pu, Lulu;Lei, Zhiwei;Li, Xin;Peng, Yutao
关键词：Nitrogen fertilization; Tea quality; Flavor components; Microbial co-occurrence networks; Sustainable agriculture
-
Synthesis and Biological Evaluation of Disulfides Based on Garlic Extract as Type III Secretion System Inhibitors against Erwinia amylovora
作者：Yi, Aoyun;Chen, Liangye;Wei, Junjie;Li, Wanjun;Wang, Bo;Cui, Zi-Ning;Zhang, Zhao-Sheng;Shi, Yu;Wang, Xiangyun
关键词：
Erwinia amylovora ; type III secretionsystem (T3SS); fire blight; disulfide compounds; inhibitors -
Inhibitory activity and mechanism of aryl furan thioesters containing 1,3,4-thiadiazole against Erwinia amylovora
作者：Wei, Junjie;Chen, Liangye;Li, Wanjun;Yi, Aoyun;Li, Wenlong;Cui, Zi-Ning;Shi, Yu;Wang, Xiangyun
关键词：
Erwinia amylovora ; pear fire blight; 1,3,4-thiadiazole; antibacterial activity; reactive oxygen species
