Asperpyrone-Type Bis-Naphtho--Pyrones with COX-2-Inhibitory Activities from Marine-Derived Fungus Aspergillus niger
文献类型: 外文期刊
第一作者: Fang, Wei
作者: Fang, Wei;Lin, Xiuping;Liu, Yonghong;Zhou, Xuefeng;Wang, Jianjiao;Tao, Huaming
作者机构:
关键词: bis-naphtho--pyrones;Aspergillus niger;COX-2-inhibitory;HPLC;MS
期刊名称:MOLECULES ( 影响因子:4.411; 五年影响因子:4.587 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Bis-naphtho--pyrones (BNPs) are an important group of aromatic polyketides derived from fungi, and asperpyrone-type BNPs are produced primarily by Aspergillus species. The fungal strain Aspergillus niger SCSIO Jcsw6F30, isolated from a marine alga, Sargassum sp., and identified according to its morphological traits and the internal transcribed spacer (ITS) region sequence, was studied for BNPs secondary metabolisms. After HPLC/MS analysis of crude extract of the fermentation broth, 11 asperpyrone-type BNPs were obtained directly and quickly by chromatographic separation in the extract, and those isolated asperpyrone-type BNPs were structurally identified by NMR and MS analyses. All of the BNPs showed weak cytotoxicities against 10 human tumor cells (IC50 > 30 M). However, three of them, aurasperone F (3), aurasperone C (6) and asperpyrone A (8), exhibited obvious COX-2-inhibitory activities, with the IC50 values being 11.1, 4.2, and 6.4 M, respectively. This is the first time the COX-2-inhibitory activities of BNPs have been reported.
分类号: O62
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