20-Hydroxyecdysone (20E) Primary Response Gene E75 Isoforms Mediate Steroidogenesis Autoregulation and Regulate Developmental Timing in Bombyx

文献类型： 外文期刊

第一作者： Li, Kang

作者： Li, Kang;Li, Sheng;Li, Kang;Li, Sheng;Li, Kang;Tian, Ling;Li, Sheng;Tian, Ling;Guo, Sanyou;Cao, Yang;Guo, Zhongjian;Zhang, Jianzhen;Zhang, Jianzhen;Gu, Shi-Hong;Palli, Subba R.

作者机构：

关键词： development;nuclear receptor;protein-protein interaction;signal transduction;steroidogenesis;Halloween genes;ROREs;feedback regulation;isoform-specific

期刊名称：JOURNAL OF BIOLOGICAL CHEMISTRY （ 影响因子：5.157； 五年影响因子：5.041 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The temporal control mechanisms that precisely control animal development remain largely elusive. The timing of major developmental transitions in insects, including molting and metamorphosis, is coordinated by the steroid hormone 20-hydroxyecdysone (20E). 20E involves feedback loops to maintain pulses of ecdysteroid biosynthesis leading to its upsurge, whereas the underpinning molecular mechanisms are not well understood. Using the silkworm Bombyx mori as a model, we demonstrated that E75, the 20E primary response gene, mediates a regulatory loop between ecdysteroid biosynthesis and 20E signaling. E75 isoforms A and C directly bind to retinoic acid receptor-related response elements in Halloween gene promoter regions to induce gene expression thus promoting ecdysteroid biosynthesis and developmental transition, whereas isoform B antagonizes the transcriptional activity of isoform A/C through physical interaction. As the expression of E75 isoforms is differentially induced by 20E, the E75-mediated regulatory loop represents a fine autoregulation of steroidogenesis, which contributes to the precise control of developmental timing.

分类号： Q5

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