Wortmannines A-C, three novel wortmannin derivatives with an unusual five-membered B ring from the endophytic fungus Talaromyces wortmannii LGT-4

文献类型： 外文期刊

第一作者： Fu, Guang-Chao

作者： Fu, Guang-Chao;Yang, Zhong-Duo;Shu, Zong-Mei;Xue, Hong-Yan;Wang, Yong-Gang;Yang, Zhong-Duo;Zhou, Shuang-Yan;Yao, Xiao-Jun;Li, Xin-Ming;Fang, Jian-Guo;Li, Xin-Ming;Fang, Jian-Guo;Yu, Hai-Tao

作者机构：

关键词： Talaromyces;Wortmannine;Structure elucidation;Cytotoxic activity

期刊名称：TETRAHEDRON LETTERS （ 影响因子：2.415； 五年影响因子：2.036 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Wortmannine A (1), a dinor-carbon wortmannin derivative with an unusual five-membered B ring, together with wortmannine B (2), a wortmannin derivative bearing an unusual five-membered B ring and lactam E-ring, and wortmannine C (3), a wortmannin derivative bearing an unusual five-membered B ring and a lactone E-ring, as well as wortmannine D (4), a 4-methyl substituted androstadiene-17-one, were purified from the zeistic culture of Talaromyces wortmannii LGT-4. The structures of 1-4 were elucidated by comprehensive NMR spectroscopy, Mosher's method and single-crystal X-ray crystallography. Additional known compounds (5-8) were also isolated. The isolates were tested for cytotoxic activities and compound 5, entonaemin A, showed anti-HL60 activity with IC(50)s of 15.0 mu M (24 h) and 12.4 mu M (48 h). (C) 2016 Elsevier Ltd. All rights reserved.

分类号： O62

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